Effect of Two Exercise Programs on Bone Strength and Architecture
| Status: | Recruiting |
|---|---|
| Conditions: | Osteoporosis |
| Therapuetic Areas: | Rheumatology |
| Healthy: | No |
| Age Range: | 60 - 75 |
| Updated: | 4/17/2018 |
| Start Date: | July 1, 2016 |
| End Date: | January 2019 |
| Contact: | Sarah J Wherry, PhD |
| Email: | sarah.wherry@ucdenver.edu |
| Phone: | 7208486475 |
Bone responds according to the load placed on it. In this study, investigators want to know
if exercise that loads the body in exercises, like walking or jogging (Ground Reaction
Forces: GRF), affects bone differently than exercises that load the joints, like weight
lifting (Joint Reaction Forces: JRF). Participants will exercise at least 3 times a week for
6 months. Measures of bone strength and mass, muscular strength, and aerobic fitness will be
taken at the beginning and the end of the 6 month program. Period blood samples will be taken
for future analysis of blood markers.
if exercise that loads the body in exercises, like walking or jogging (Ground Reaction
Forces: GRF), affects bone differently than exercises that load the joints, like weight
lifting (Joint Reaction Forces: JRF). Participants will exercise at least 3 times a week for
6 months. Measures of bone strength and mass, muscular strength, and aerobic fitness will be
taken at the beginning and the end of the 6 month program. Period blood samples will be taken
for future analysis of blood markers.
Inclusion Criteria:
- non-smoker
- in generally good health
- not physically active (less than 60 minutes of purposeful exercise/week)
- able to travel to the exercise facility a minimum of 3 times/week
Exclusion Criteria:
- use of glucocorticoids
- abnormal resting EKG
- angina and/or evidence of acute myocardial ischemia during a treadmill test
- resting blood pressure above 150 mmHg systolic of 90 mmHg diastolic
- anti-resorptive drug use in the last 2 years
- initiation of treatments that could impact bone metabolism (diuretics, hormones, bine
anabolic agents) in the prior 6 months
- dual-energy x-ray absorptiometry (DXA) t-score <+ -2.5 at the femoral neck and/or
lumbar spine
- serum vitamin D concentration <20 ng/mL
- uncontrolled thyroid disease
- any contraindications to regular exercise
We found this trial at
2
sites
13001 E 17th Pl
Aurora, Colorado 80045
Aurora, Colorado 80045
(303) 724-5000
Principal Investigator: Rebecca Boxer, MD, MS
Phone: 7208486475
University of Colorado Anschutz Medical Campus Located in the Denver metro area near the Rocky...
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Denver, Colorado 80220
Principal Investigator: Robert Schwartz, MD
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