To Evaluate Safety, Pharmacokinetics and Pharmacodynamics of MEDI6012 in Subjects With Stable Coronary Artery Disease

Inclusion Criteria:

- Men and women 40 - 75 years old

- History of Stable CAD

- Currently receiving statin as standard of care

Exclusion Criteria:

- Severe angina pectoris symptoms

- High-risk coronary or carotid artery disease that will likely require surgical or
percutaneous intervention during the study period

- Hospitalization for heart failure within 12 months prior to screening

- Uncontrolled Hypertension

- Within 6 months prior to screening, a history of ACS or hospitalization for heart
failure

- Clinically significant abnormalities in rhythm, conduction or morphology of ECG

- Subjects with transplanted heart, left ventricular assist device, implanted pacemaker,
implantable cardioverter defibrillator, or cardiac resynchronization therapy

- Untreated life-threatening ventricular arrhythmias

- History, within 12 months prior to screening, of myocarditis or restrictive
pericarditis, or hemodynamically significant valvular hear disease or aortic disease

- Undergone major surgery with in 3 months prior to screening or has planned major
surgery during the study period