Eribulin and Lenvatinib in Advanced Solid Tumors

This is a phase II clinical trial of the combination of eribulin, and Lenvatinib. A cycle
will be defined as 21 days. Eribulin will be given on days 1 and 8 of each cycle. Lenvatinib
will be given daily during each cycle.

Inclusion Criteria:

- Stage IV breast cancer, stage IV NSCLC (Non-Small Cell Lung Cancer) (, stage IV
sarcoma

- ECOG (Eastern Cooperative Oncology Group) PS (Performance Status) 0-2

- Measurable disease

- No more than 4 prior chemotherapeutic regimens for metastatic disease

- Patients must be >/= 18 years.

- Patients may not have received eribulin or lenvatinib previously

- Patients must have a life expectancy of greater than 12 weeks.

- Patients may have had a prior diagnosis of cancer if it has been > 5 years since their
last treatment and are considered free of disease.

- Patients must have normal organ and marrow function as defined below:

Leukocytes ≥ 3,000/uL Absolute neutrophil count ≥ 1,500/uL Platelets ≥ 100,000/uL Child
Pugh score ≤ 10 Patients must be able to swallow and retain oral medication. All patients
must have given signed, informed consent prior to registration on study.

Exclusion Criteria:

- Women who are pregnant or lactating are not eligible for study treatment.

- Patients who are undergoing concomitant radiotherapy are NOT eligible for
participation.

- Patients who are receiving any other investigational agents or concurrent anticancer
therapy are NOT eligible for participation. Previous systemic treatment and/or
radiation therapy is allowed with a 14 day washout period prior to registration.

- Lesions that have been radiated previously cannot be considered target lesions

- Prior treatment related side effects must have resolved to < Grade 2 severity per
Common Terminology Criteria for Adverse Events (CTCAE version 4.03), except alopecia
and infertility.

- Patients who are taking any herbal (alternative) medicines are NOT eligible for
participation. Patients must be off any such medications by the time of registration.

- Patients with known brain metastases are NOT eligible for participation unless the
brain metastases are treated (either with surgical excision, stereotactic radiosurgery
or radiotherapy) and have been stable for at least 4 wks per MR performed, the patient
is asymptomatic and has discontinued corticosteroids if taken for that purpose.

- Patients with any of the following conditions or complications are NOT eligible for
participation:

1. GI tract disease resulting in an inability to take oral medication

2. Malabsorption syndrome

3. Require IV alimentation

4. History of prior surgical procedures affecting absorption

5. Uncontrolled inflammatory GI disease (e.g., Crohn's, ulcerative colitis).

6. Hypersensitivity of any of the components of eribulin or lenvatinib

7. History of significant neurological ( no neuropathy more than grade 2) or
psychiatric disorders

8. Significant non neoplastic liver disease (Cirrhosis, active chronic hepatitis)

9. Immunocompromised subjects, including patients with human immunodeficiency virus

10. Significant non neoplastic renal disease

11. Active infection requiring systemic therapy.

12. Significant cardiovascular impairment: history of congestive heart failure
greater than New York Heart Association (NYHA) Class II, uncontrolled arterial
hypertension, unstable angina, myocardial infarction or stroke within 6 months of
the first dose of study drug; or cardiac arrhythmia requiring medical treatment

13. Prolongation of QTc interval to more than 480 milliseconds when electrolyte
balance is normal

14. Major surgery within 4 weeks prior to first dose of the study drug.