An Study of Transcranial Direct Current Stimulation in Adults With ADHD

Inclusion Criteria:

- Male and female adults 18-65 years of age.

- A diagnosis of childhood onset ADHD, meeting the Diagnostic and Statistical Manual of
Mental Disorders, Fifth Edition (DSM-5) [American Psychiatric Association, 2013]
criteria, including at least 5 moderate inattentive or impulsive-hyperactive symptoms,
and onset of several symptoms of inattentive or of impulsive/hyperactive traits by the
age of 12.

- English-speaking.

Exclusion Criteria:

- Current or past history of mental retardation, severe sensory impairment such as deafness
or blindness, hypomania, mania, psychosis, suicidal or homicidal behavior.

Current moderate to severe symptoms of a mental health condition other than ADHD, assessed
using a clinical evaluation and the Adult Self Report Scale that, in the judgment of the
investigator, may jeopardize subject safety or interfere with their ability to participate
in the study. Specifically, this will include current clinical diagnosis of moderate to
severe major depression, or a score on the depressive problem subscale of the ASRS that
falls in the clinically significant range.

- Substance use disorder within the past 6 months.

- Any significant medical condition, that, in the judgment of the investigator, may
jeopardize subject safety.

- Pregnant females.

- Inability or unwillingness to participate in study procedures.

- Contraindication to tDCS: history of epilepsy, metallic implants in the head and neck,
brain stimulators, vagus nerve stimulators, VP shunt, or pacemakers.

- Skin conditions that may make the application of, treatment with, and removal of the
tDCS hardware painful as per the discretion of the clinician.

- Current use of a medication considered to be therapeutic for ADHD. If a subject is
taking a medication that is considered by study investigators to potentially treat
ADHD (eg. a stimulant, atomoxetine, buproprion, modafanil, serotonin-norepinephrine
reuptake inhibitor, guanfacine or clonidine) they must stop use of this medication for
at least 5 half lives of the drug under physician guidance prior to study
participation. Subjects will not enter the study if it would require stopping a
medication that is optimally and comfortably managing a clinical concern.