The SNORES Randomized Clinical Trial

The investigators' goal is to perform a randomized clinical trial among women with PCOS who
present for infertility treatment. Our primary outcome is to determine if screening women
with PCOS, and treating those with confirmed sleep apnea, will lead to more ovulatory
cycles. Our sub-aims are to describe the rate of OSA and sleep symptoms in patients with
PCOS, to see if current sleep questionnaires correlate to a diagnostic sleep study, to
describe the correlation between OSA and biomarkers of glucose homeostasis in women with
PCOS, to investigate health related quality of life between the groups, to compare perinatal
outcomes between the groups, and to evaluate the composition of breastmilk among women who
choose to breastfeed.

Inclusion Criteria

- Females 18 - 35 years old.

- Receiving care at University of South Florida

- Polycystic ovarian syndrome defined by the modified Rotterdam criteria

- Able to speak and understand as well as give informed consent in English

Exclusion Criteria

- Late onset congenital adrenal hyperplasia

- Cushings disease

- Androgen-secreting tumors

- Previous diagnosis of obstructive sleep apnea

- Current use of over the counter or prescribed sleep medications.

- Examples of medications that exclude a patient from this study include but are
not limited to Unisom, Ambien or Lunesta.

- Patients who are taking non-prescribed herbal medications for sleep will not be
excluded from the study. Examples of these include but are not limited to
melatonin, chamomile, or valerian.

- Untreated thyroid disease

- Prolactin excess

- Patients with the following medical conditions will be excluded from the study as
portable sleep apnea monitors are not indicated in patients with severe pulmonary
disease, neuromuscular disease, or congestive heart failure.