Impact of Daylight on Patients With Acute Myocardial Infarction
| Status: | Recruiting |
|---|---|
| Conditions: | Cardiology, Cardiology, Cardiology |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | 18 - 90 |
| Updated: | 1/6/2019 |
| Start Date: | July 2015 |
| End Date: | July 2019 |
| Contact: | Tobias Eckel, MD, PhD |
| Email: | tobias.eckel@ucdenver.edu |
Impact of Daylight on Period 2 Protein and Glycolytic Enzymes in Human Buccal Mucosa and Blood Samples
The study tests if intense light could be a potential therapy in humans after myocardial
infarction by inducing Per2.
infarction by inducing Per2.
Damage to the heart caused by a myocardial infarction (heart attack) occurs most often during
the early morning hours (6AM). Thus, the involvement of the circadian system (circa=
approximately day) has been suggested. The circadian system in humans or animals is based on
the rotation of the earth with day and night phases. When humans (or animals) wake up light
shines in their eyes and the body receives a signal that the day starts. For the human body
it means that certain proteins (named clock, period etc) are produced. The protein that
determines the length of a day (awake and sleep period) is called Period 2 (Per2). Recent
data indicated that the Per2 protein in hearts from mice is induced after daylight exposure
(daylight with an intensity comparable to a bright day at the beach was used, approx. 10 000
LUX). This more Per2 was able to protect the heart from being damaged by no blood going to
the heart (protection from a heart attack). This protection was based on a more efficient use
of sugars (carbohydrates). Thereby the heart needs less oxygen. Current data indicate that
human Per2 is also induced by light exposure and can be detected in human plasma samples.
In this study Per2 transcript and protein levels will be analyzed in patients that just
experienced a heart attack with and without intense light (daylight) therapy utilizing blood
samples (erythrocytes and leukocytes).
the early morning hours (6AM). Thus, the involvement of the circadian system (circa=
approximately day) has been suggested. The circadian system in humans or animals is based on
the rotation of the earth with day and night phases. When humans (or animals) wake up light
shines in their eyes and the body receives a signal that the day starts. For the human body
it means that certain proteins (named clock, period etc) are produced. The protein that
determines the length of a day (awake and sleep period) is called Period 2 (Per2). Recent
data indicated that the Per2 protein in hearts from mice is induced after daylight exposure
(daylight with an intensity comparable to a bright day at the beach was used, approx. 10 000
LUX). This more Per2 was able to protect the heart from being damaged by no blood going to
the heart (protection from a heart attack). This protection was based on a more efficient use
of sugars (carbohydrates). Thereby the heart needs less oxygen. Current data indicate that
human Per2 is also induced by light exposure and can be detected in human plasma samples.
In this study Per2 transcript and protein levels will be analyzed in patients that just
experienced a heart attack with and without intense light (daylight) therapy utilizing blood
samples (erythrocytes and leukocytes).
Inclusion Criteria:
- Patients with an acute myocardial infarction
- Healthy volunteers
- Must speak and understand English
Exclusion Criteria:
- Patients with an acute myocardial infarction but are too sick, e.g. severe symptoms,
chest pain, generally unstable, etc.
We found this trial at
1
site
Click here to add this to my saved trials
