A Study of Obinutuzumab, Polatuzumab Vedotin, and Lenalidomide in Relapsed or Refractory Follicular Lymphoma (FL) and Rituximab in Combination With Polatuzumab Vedotin and Lenalidomide in Relapsed or Refractory Diffuse Large B-Cell Lymphoma (DLBCL)

Inclusion Criteria:

- Age greater than or equal to (>/=) 18 years

- Eastern Cooperative Oncology Group (ECOG) performance status of 0, 1, or 2

- For obinutuzumab in combination with polatuzumab vedotin and lenalidomide (G + Pola +
Len) treatment group: R/R FL after treatment with at least one prior
chemoimmunotherapy regimen that included an anti-CD20 monoclonal antibody and for
which no other more appropriate treatment option exists as determined by the
investigator

- For rituximab in combination with polatuzumab vedotin and lenalidomide (R + Pola +
Len) treatment group: R/R DLBCL after treatment with at least one prior
chemoimmunotherapy regimen that included an anti-CD20 monoclonal antibody in patients
who are not eligible for autologous stem-cell transplantation or who have experienced
disease progression following treatment with high-dose chemotherapy plus autologous
stem-cell transplantation

- Histologically documented CD20-positive B-cell lymphoma as determined by the local
laboratory

- fluorodeoxyglucose (FDG)-avid lymphoma (i.e., positron emission tomography
(PET)-positive lymphoma)

- At least one bi-dimensionally measurable lesion

- Agreement to remain abstinent or use adequate contraception, among women or men of
childbearing potential

Exclusion Criteria:

- Grade 3b follicular lymphoma

- History of transformation of indolent disease to diffuse large B-cell lymphoma (DLBCL)

- Known CD20-negative status at relapse or progression

- Central nervous system (CNS) lymphoma or leptomeningeal infiltration

- Prior allogeneic stem-cell transplantation (SCT), or autologous SCT within 100 days
prior to Day 1 of Cycle 1

- Current use of systemic immunosuppressant(s), or prior anti-cancer therapy to include:
lenalidomide, fludarabine, or alemtuzumab within 12 months; radioimmunoconjugate
within 12 weeks; mAb or antibody-drug conjugate within 4 weeks; or
radiotherapy/chemotherapy/hormone therapy/targeted small-molecule therapy within 2
weeks prior to Day 1 of Cycle 1

- Active infection

- Positive for human immunodeficiency virus (HIV) or hepatitis B or C

- Receipt of a live virus vaccine within 28 days prior to Day 1 of Cycle 1

- Poor hematologic, renal, or hepatic function

- Pregnant or lactating women

- Life expectancy less than (<) 3 months