Study of NGM282 in Subjects With Functional Constipation and Healthy Individuals
| Status: | Completed |
|---|---|
| Conditions: | Constipation |
| Therapuetic Areas: | Gastroenterology |
| Healthy: | No |
| Age Range: | 18 - 65 |
| Updated: | 4/17/2018 |
| Start Date: | December 2015 |
| End Date: | January 2017 |
Study of the Pharmacodynamics of NGM282 on Colonic Transit, Bile Acid Homeostasis, and Fecal Fat in Subjects With Functional Constipation and Healthy Individuals
The purpose of this study is to determine the effect of NGM282 on colonic transit, bile acid
homeostasis, and fecal fat in subjects with functional constipation and healthy individuals.
homeostasis, and fecal fat in subjects with functional constipation and healthy individuals.
Inclusion Criteria:
- Functional constipation confirmed by modified Rome III criteria or Healthy Volunteer
Exclusion Criteria:
- Structural or metabolic diseases/conditions that affect the GI system
- Diagnosis of dyspepsia, IBS, or significant gastrointestinal symptoms
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