Trial of Linaclotide in Patients With Irritable Bowel Syndrome With Constipation (IBS-C)

Inclusion Criteria:

- Patient has completed a colonoscopy according to the AGA criteria, with no clinically
significant findings

- Patient has no clinically significant findings on a physical examination and clinical
laboratory tests

- Patient meets protocol criteria for diagnosis of IBS-C

- Patient demonstrates continued IBS-C through Pretreatment Period

- Patient maintains a minimum level of compliance with daily diary

Exclusion Criteria:

- Patient has history of loose or watery stools

- Patient has symptoms of or been diagnosed with a medical condition that may
contribute to abdominal pain

- Patient has a structural abnormality of the gastrointestinal (GI) tract or a disease
or condition that can affect GI motility

- Patient has any protocol-excluded or clinically significant medical or surgical
history that could confound the study assessments