Intraoperative Imaging of Pulmonary Adenocarcinoma

The goal is to improve the intraoperative identification of tumor cells at positive margins
and regional metastases that may be missed by a surgeon during a pulmonary resection.
Improved identification of tumor cells will result in superior disease clearance and more
accurate clinical staging. The investigators hypothesize that targeted fluorescent imaging
during surgery will improve identification of positive margins and metastases. Since folate
receptor alpha (FR ) is expressed on 55% of resectable lung cancer, the investigators will
utilize a fluorescent probe that targets these tumors. As real-time imaging provides more
information to the surgeon, more personalized and directed operations can be conducted. This
work will allow for more preservation of normal tissue, decreased morbidity, decreased
surgical time, increased surgical confidence, improved cancer detection, decreased
unnecessary surgery and ultimately improved tumor free survival. This technology should
transform clinical surgery from an art that depends fully on the human factor to a procedure
that has precision and fail safes.

Inclusion Criteria:

- lung cancer

- surgical candidate

- operable

- resectable

Exclusion Criteria:

- no allergies to contrast dyes