The Study of Skeletal Muscle Blood Flow in Response to the Medication Ranolazine at Rest and With Exercise
| Status: | Recruiting |
|---|---|
| Conditions: | Neurology |
| Therapuetic Areas: | Neurology |
| Healthy: | No |
| Age Range: | 18 - 45 |
| Updated: | 4/21/2016 |
| Start Date: | December 2015 |
| End Date: | December 2016 |
| Contact: | Katie Sy |
| Email: | katrina.sy@cshs.org |
| Phone: | 3102487641 |
Ranolazine and Skeletal Muscle Perfusion
This pilot study tests the hypothesis that the medication Ranolazine improves blood flow to
the skeletal muscle during exercise. The investigators will use cutting edge technology with
contrast enhanced ultrasound to visualize the microvascular blood supply to the forearm.
Animal studies have shown reversal of muscle damage with improved delivery of blood to the
exercising muscle. This research aims to understand the mechanism of action of this
medication in a way it has never been studied before. The results may help benefit
individuals with muscular Dystrophy in the future.
the skeletal muscle during exercise. The investigators will use cutting edge technology with
contrast enhanced ultrasound to visualize the microvascular blood supply to the forearm.
Animal studies have shown reversal of muscle damage with improved delivery of blood to the
exercising muscle. This research aims to understand the mechanism of action of this
medication in a way it has never been studied before. The results may help benefit
individuals with muscular Dystrophy in the future.
The subjects are asked to perform a graded hand-grip exercise while blood flow to the
skeletal muscle is visualized by contrast enhanced ultrasound.
This is done at baseline and after taking the medication under study, Ranolazine.
skeletal muscle is visualized by contrast enhanced ultrasound.
This is done at baseline and after taking the medication under study, Ranolazine.
Inclusion Criteria:
- Healthy man, aged 18 to 45 years, currently taking no medication. OR
- Clinical diagnosis of Becker Muscular Dystrophy (BMD), aged 18 to 45 years, and
currently taking no medication.
Exclusion Criteria:
- Hypertension, diabetes, heart failure, liver disease
- ECG evidence of prolonged QT interval
We found this trial at
1
site
8700 Beverly Blvd # 8211
Los Angeles, California 90048
Los Angeles, California 90048
(1-800-233-2771)
Principal Investigator: Ronald G Victor, MD
Phone: 310-248-8080
Cedars Sinai Med Ctr Cedars-Sinai is known for providing the highest quality patient care. Our...
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