CAP-Ketamine for Antidepressant Resistant PTSD
| Status: | Recruiting |
|---|---|
| Conditions: | Psychiatric, Psychiatric |
| Therapuetic Areas: | Psychiatry / Psychology |
| Healthy: | No |
| Age Range: | 18 - 70 |
| Updated: | 1/23/2019 |
| Start Date: | April 18, 2016 |
| End Date: | September 30, 2019 |
| Contact: | Lynnette Averill |
| Email: | Lynnette.Averill@va.gov |
The purpose of this study is to test the safety and efficacy of repeated doses of ketamine as
compared to placebo, in reducing symptoms of Posttraumatic Stress Disorder (PTSD) in an
active duty military and Veteran population.
compared to placebo, in reducing symptoms of Posttraumatic Stress Disorder (PTSD) in an
active duty military and Veteran population.
In this 2-site clinical trial, intended to evaluate the safety and efficacy of repeated doses
of ketamine for treatment resistant PTSD, Veterans and active duty military personnel who
meet criteria for PTSD and the additional inclusion and exclusion criteria will be randomized
to one of three treatment arms (placebo, low dose ketamine, high dose ketamine). Participants
receive the study drug via intravenous infusion twice per week for 4-weeks.
of ketamine for treatment resistant PTSD, Veterans and active duty military personnel who
meet criteria for PTSD and the additional inclusion and exclusion criteria will be randomized
to one of three treatment arms (placebo, low dose ketamine, high dose ketamine). Participants
receive the study drug via intravenous infusion twice per week for 4-weeks.
Inclusion Criteria:
- male or female Veterans or active duty military personnel between the ages of 18 and
70 years
- diagnosis of PTSD
- history of trialing one or more antidepressant medications with little to no PTSD
symptom improvement
- ability to provide written informed consent
Exclusion Criteria:
- females who are currently pregnant or breastfeeding
- current risk for suicide
- history of severe head injury
We found this trial at
2
sites
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West Haven, Connecticut 06516
Principal Investigator: John H. Krystal, MD
Phone: 203-932-5711
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