Retrospective Study of IBS-D Patients Previously Receiving SBI

- The first collection of information (Visit 1 - Chart Report Form) will be for the visit
at which the SOC therapy, utilized immediately before the introduction of EnteraGam,
was initiated. This data point will serve as the baseline for that SOC therapy.

- The second collection of information (Visit 2 - Chart Report Form) will be for the
visit at which the original prescription for EnteraGam was written and the patient was
instructed to begin the therapy. Captured data will consist of information contained in
the patient's chart for a minimum of eight weeks and a maximum of 12 weeks prior to
initiation of EnteraGam therapy. This data point will serve as the baseline for
initiation of EnteraGam therapy.

- The third collection point (Visit 3 - Chart Report Form) will be at the next patient
visit to the clinic - provided that visit is a minimum of eight weeks following
initiation of EnteraGam therapy.

Inclusion Criteria:

- Patient is at least 18 years of age at the initiation of EnteraGam therapy.

- Patient has been previously diagnosed with IBS-D by the physician and has undergone
at least one course of SOC treatment prior to receiving EnteraGam.

- Patient has completed a minimum of eight weeks of EnteraGam therapy for his / her
IBS-D.

- There is recorded information regarding patient response to SOC or EnteraGam for
stool frequency/consistency and abdominal pain

Exclusion Criteria:

- Patient has not taken EnteraGam for a minimum of eight weeks or has not used the
product according to the directions provided by the prescribing physician.

- Patient has not consented to the use of their clinical data in this retrospective
clinical investigation.