Study of FF-10502-01 in Patients With Advanced Solid Tumors and Lymphomas

Subjects will receive doses of FF-10502-01 intravenously (IV) weekly for three weeks,
repeated every 28 days (= 1 cycle). Disease assessments, based on computed tomography (CT),
magnetic resonance image (MRI), and, for lymphoma, [18F]-fluorodeoxyglucose positron emission
tomography (FDG-PET) scans, will be obtained at Week 8 and every 8 weeks thereafter until
documented progression of disease (PD). Subjects who demonstrate clinical benefit will be
allowed to continue therapy with FF-10502-01 until progression of disease, observation of
unacceptable adverse events, intercurrent illness or changes in the subject's condition that
prevents further study participation.

Inclusion Criteria:

- Males and females ≥ 18 years of age

- Histologically or cytologically confirmed advanced or metastatic solid tumor or l
lymphoma, that is refractory to standard therapy, relapsed after standard therapy, or
for which no standard therapy available that is expected to improve survival by at
least three months

- At least 4 weeks beyond the last chemotherapy (or ≥ 5 half-lives for targeted agents,
whichever is shorter), radiotherapy, major surgery or experimental treatment and
recovered from all acute toxicities (≤ Grade 1)

- Adequate performance status: Eastern Cooperative Oncology Group (ECOG) ≤ 2

- Life expectancy of ≥ 3 months

- Adequate hematologic parameters without ongoing transfusional support:

- Hemoglobin (Hb) ≥ 9 g/dL

- Absolute neutrophil count (ANC) ≥ 1.0 x 109 cells/L

- Platelets ≥ 100 x 109 cells/L

- Adequate renal and hepatic function:

- Creatinine ≤ 1.5 x the upper limit of normal (ULN), or calculated creatinine clearance
≥ 60 mL/minute x 1.73 m2 per the Cockcroft-Gault formula

- Total bilirubin ≤ 2 times the upper limit of normal (ULN) unless due to Gilbert's
disease

- ALT/AST ≤ 2.5 times ULN, or < 5 times ULN for subjects with liver metastases

- QT interval corrected for rate (QTc) ≤ 480 msec on the electrocardiogram (ECG)
obtained at Screening

- Negative serum pregnancy test within 14 days prior to the first dose of study therapy
for women of child-bearing potential (WCBP), defined as a sexually mature woman who
has not undergone a hysterectomy or who has not been naturally post-menopausal for at
least 24 consecutive months (i.e., who has had menses any time in the preceding 24
consecutive months). Sexually active WCBP and male subjects must agree to use adequate
methods to avoid pregnancy (oral, injectable, or implantable hormonal contraceptive;
tubal ligation; intra-uterine device; barrier contraceptive with spermicide; or
vasectomized partner) throughout the study and for 28 days after the completion of
study treatment.

- Ability to provide written informed consent

Exclusion Criteria:

- Serious cardiac condition within the last 6 months, such as uncontrolled arrhythmia,
myocardial infarction, unstable angina or heart disease defined by the New York Heart
Association (NYHA) Class III or Class IV

- Concomitant medication(s) that may cause QTc prolongation or induce Torsades de
Pointes, with the exception of anti-microbials that are used as standard of care to
prevent or treat infections and other such drugs that are considered by the
Investigator to be essential for patient care

- Active central nervous system (CNS) malignant disease in subjects with a history of
CNS malignancy. Subjects with stable, prior or currently treated brain metastases are
allowed.

- Known positive for human immunodeficiency virus (HIV), hepatitis B virus surface
antigen (HBsAg) or hepatitis C virus (HCV)

- Active infection requiring intravenous (IV) antibiotic usage within the last week
prior to study treatment

- Any other medical intervention or other condition which, in the opinion of the
Principal Investigator, could compromise adherence to study requirements or confound
the interpretation of study results

- Pregnant or breast-feeding