A Study to Evaluate SAGE-547 in Patients With Severe Postpartum Depression

Key Inclusion Criteria:

- Subject either must have ceased lactating at Screening; or if still lactating at
Screening, must have already fully and permanently weaned their infant(s) from
breastmilk; or if still actively breastfeeding at Screening, must agree to cease
giving breastmilk to their infant(s) prior to receiving study drug.

- Subject has had a Major Depressive Episode that began no earlier than the third
trimester and no later than the first 4 weeks following delivery, as diagnosed by
Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I)

- Subject is ≤ six months postpartum

- Subject must be amenable to IV therapy

Key Exclusion Criteria:

- Active psychosis

- Attempted suicide associated with index case of postpartum depression

- Medical history of seizures

- Medical history of bipolar disorder

Note: suicidal ideation is not an exclusion. Other protocol-defined inclusion/exclusion
criteria may apply.