Effect of Electronic Cigarettes on Platelets, Endothelium and Inflammation
| Status: | Not yet recruiting |
|---|---|
| Conditions: | Smoking Cessation |
| Therapuetic Areas: | Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | 21 - 40 |
| Updated: | 12/1/2016 |
| Start Date: | March 2017 |
| End Date: | October 2017 |
| Contact: | Matthew Vorsanger, MD |
| Email: | mv751@nyumc.org |
Acute Effects of Electronic Cigarettes on Platelet, Vascular Endothelial Function, and Inflammation in Healthy Active Smokers
The primary purpose of this study is to evaluate the acute effects of electronic cigarette
(e-cigarette) smoking on measurable biomarkers of platelet function, vascular endothelial
function and inflammation in healthy active smokers. 10 healthy subjects, smokers, with no
other medical conditions will be included in this study and measurements will be obtained at
baseline and after smoking an e-cigarette. The study will contribute to the understanding of
the effects of e-cigarettes on cardiovascular physiology, specifically establishing if the
use of e-cigarettes increases platelet aggregation and platelet activation when compared to
baseline in healthy active smokers, if the use of e-cigarettes decreases brachial artery
flow-mediated dilation compared to baseline in healthy active smokers, and to determine the
association between biomarkers of inflammation, platelet function, and vascular endothelial
function before and after use of e-cigarettes.
(e-cigarette) smoking on measurable biomarkers of platelet function, vascular endothelial
function and inflammation in healthy active smokers. 10 healthy subjects, smokers, with no
other medical conditions will be included in this study and measurements will be obtained at
baseline and after smoking an e-cigarette. The study will contribute to the understanding of
the effects of e-cigarettes on cardiovascular physiology, specifically establishing if the
use of e-cigarettes increases platelet aggregation and platelet activation when compared to
baseline in healthy active smokers, if the use of e-cigarettes decreases brachial artery
flow-mediated dilation compared to baseline in healthy active smokers, and to determine the
association between biomarkers of inflammation, platelet function, and vascular endothelial
function before and after use of e-cigarettes.
Inclusion Criteria:
- Adult English speaking subjects able and willing to provide written informed consent
- Active tobacco cigarette smoker
- History of active smoking tobacco cigarettes for 3-10 years (at least 10 cigarettes
per day). The rational for inclusion of active smokers is based on prior data showing
that most e-cigarette users have smoked moderate to high amount of tobacco cigarettes
in the past
- No other use of alternative tobacco or nicotine products
- No history of hypertension, diabetes, cardiovascular disease, stroke, peripheral
arterial disease, asthma or other chronic lung disease.
Exclusion Criteria:
- Use of aspirin, clopidogrel, prasugrel, ticagrelor, warfarin, statins, colchicine,
nitrates, steroids, fish oil, omega-3 fatty acids, or any other anti-inflammatory,
antithrombotic or anticoagulant agent in the last week
- History of adverse reactions to e-cigarettes
We found this trial at
1
site
550 1st Ave
New York, New York 10016
New York, New York 10016
(212) 263-7300
Principal Investigator: Stuart Katz, MD
New York University School of Medicine NYU School of Medicine has a proud history that...
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