Dry Eye in Women With Turner Syndrome and Women With Premature Ovarian Failure
| Status: | Completed |
|---|---|
| Conditions: | Other Indications, Women's Studies, Women's Studies, Women's Studies |
| Therapuetic Areas: | Other, Reproductive |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 2/16/2018 |
| Start Date: | May 7, 2007 |
| End Date: | November 13, 2014 |
Ocular Impact of X Chromosome Karyotype and Sex Hormones in Turner Syndrome
Premature ovarian failure (POF) is known to be associated with an increased risk of ocular
surface disease (dry eye), likely due to the reduction of both estrogens and androgens seen
in this condition. From preliminary data, we suspect that women with Turners syndrome (45,
XO), a genetic abnormality that affects sex hormone levels, are also at increased risk of
ocular surface disease. Comparing POF and TS women may allow us to distinguish different
mechanisms for ocular surface disease, due to the different etiologies of hormonal (estrogen
and androgen) alterations posed by POF and TS.
surface disease (dry eye), likely due to the reduction of both estrogens and androgens seen
in this condition. From preliminary data, we suspect that women with Turners syndrome (45,
XO), a genetic abnormality that affects sex hormone levels, are also at increased risk of
ocular surface disease. Comparing POF and TS women may allow us to distinguish different
mechanisms for ocular surface disease, due to the different etiologies of hormonal (estrogen
and androgen) alterations posed by POF and TS.
Premature ovarian failure (POF) is known to be associated with an increased risk of ocular
surface disease (dry eye), likely due to the reduction of both estrogens and androgens seen
in this condition. From preliminary data, we suspect that women with Turners syndrome (45,
XO), a genetic abnormality that affects sex hormone levels, are also at increased risk of
ocular surface disease. Comparing POF and TS women may allow us to distinguish different
mechanisms for ocular surface disease, due to the different etiologies of hormonal (estrogen
and androgen) alterations posed by POF and TS.
surface disease (dry eye), likely due to the reduction of both estrogens and androgens seen
in this condition. From preliminary data, we suspect that women with Turners syndrome (45,
XO), a genetic abnormality that affects sex hormone levels, are also at increased risk of
ocular surface disease. Comparing POF and TS women may allow us to distinguish different
mechanisms for ocular surface disease, due to the different etiologies of hormonal (estrogen
and androgen) alterations posed by POF and TS.
- INCLUSION CRITERIA:
1. Ability to understand and give informed consent.
2. Meet the diagnostic criteria for TS (45, X0) or premature ovarian failure OR age
matched control for study participant with TS or POF.
3. For non Turner syndrome subjects only - Negative pregnancy test or post
menopausal status for greater than or equal to 1 year.
4. Karyotype of XO for TS subjects or XX for POF and age matched control subjects.
EXCLUSION CRITERIA:
1. Persons less than 18 years old.
2. Persons with ophthalmic diseases associated with ocular surface disease.
3. Hyperprolactinemia.
4. Cushing s syndrome.
5. Other endocrine disorders which impact sex steroid hormones.
6. AIDS
7. Pregnancy or lactation.
8. For age matched control population ONLY- complaints of dry eye.
9. For age matched control population ONLY- oral contraceptives or menopausal hormone
therapy or any medications which alter sex hormone levels in the blood or chronic
usage of medications that induce dry eye.
We found this trial at
1
site
9000 Rockville Pike
Bethesda, Maryland 20892
Bethesda, Maryland 20892
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