Intensity-Modulated Proton Therapy (IMPT) or TransOral Robotic Surgery (TORS) for the Treatment of Low-Risk Oropharynx Squamous Cell

Baseline Visit:

If participant agrees to take part in this study, they will complete the following tests and
procedures at their baseline visit. This baseline visit will take place before participant's
treatment with IMPT or TORS:

- Participant will complete questionnaires about any symptoms of cancer they may be having
and how they affect their daily life at work and at home, their diet, and their speech.

- Participant will complete the Dysphagia Inventory. This is a questionnaire about how
difficult it is to swallow.

- The study staff will measure how wide participant can open their jaw to see if their
treatment may cause any jaw opening limitations.

It should take about 30 minutes to complete all of the questionnaires.

As part of participant's baseline visit, information below will be collected from their
medical record:

- Participant's medical history

- The results of participant's physical exam including their weight and any recent weight
loss.

- Any other diseases participant may have and any drugs they are currently taking.

- Participant's current smoking status and smoking history.

Activity Bands:

The study staff will either give participant an activity band at their baseline visit or they
will be mailed an activity wristband. Participant will be asked to wear the band 24 hours a
day for 1 week leading up to all study visits. The wristband will record how active
participant is and how much they sleep. The study staff will show participant how to wear and
use the wristband.

Study Visits:

Participant will complete the following study procedures after they complete treatment with
either IMPT or TORS, and at 3 and 6 months after that.

- The data from participant's wristband will be collected.

- Participant will complete the same questionnaires they did at baseline.

- At participant's 3 month visit only, the study staff will measure how wide they can open
their jaw to see if their treatment may cause any jaw opening limitations.

IMPT patients only:

If participant is receiving IMPT, they will complete the questionnaires they completed at the
baseline visit once a week while they are receiving treatment.

Length of Study:

Participant's active participation in this study will be over after the 6 month study visit.

Participant will return the wristband to the study staff after their participation is over.
If participant loses or damages the wristband while they are on study, another one will be
provided to them at no cost.

This is an investigational study.

Up to 44 participants will take part in this study. All will be enrolled at MD Anderson.

Inclusion Criteria:

1. Age ≥ 18 years

2. Histologically documented or suspected, previously untreated OPSCC (Clinical Stage
I-Va; Tx,0-2, N0-2b) eligible for standard of care single-modality treatment with
either IMPT or TORS. Patients with suspected OPSCC must have a diagnosis confirmed
prior to treatment per the current clinical standard of care

3. Eastern Cooperative Oncology Group (ECOG) = 0, 1, or 2

Exclusion Criteria: