A Trial Comparing Cardiovascular Safety of Degarelix Versus Leuprolide in Patients With Advanced Prostate Cancer and Cardiovascular Disease



Status:Recruiting
Conditions:Prostate Cancer, Cancer, Peripheral Vascular Disease
Therapuetic Areas:Cardiology / Vascular Diseases, Oncology
Healthy:No
Age Range:Any
Updated:3/30/2019
Start Date:April 2016
End Date:July 2021
Contact:Global Clinical Compliance
Email:DK0-Disclosure@ferring.com

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Trial Summary
Trial Overview
Inclusion Criteria

A Multi-Center, Randomized, Assessor-Blind, Controlled Trial Comparing the Occurrence of Major Adverse Cardiovascular Events (MACEs) in Patients With Prostate Cancer and Cardiovascular Disease Receiving Degarelix (Gonadotropin-Releasing Hormone (GnRH) Receptor Antagonist) or Leuprolide (GnRH Receptor Agonist)

The purpose of this trial is to test if a marketed drug for advanced prostate cancer
(FIRMAGON) can reduce the risk of cardiovascular complications as compared to another
marketed drug for advanced prostate cancer (LUPRON DEPOT) in patients with prostate cancer
and cardiovascular disease.


Inclusion Criteria:

- Advanced prostate cancer

- Indication to initiate androgen deprivation therapy (ADT)

- Predefined cardiovascular disease

Exclusion Criteria:

- Previous or current hormonal management of prostate cancer (unless terminated at least
12 months prior to trial)

- Acute cardiovascular disease in the previous 30 days
We found this trial at
61
sites
Alaska Clinical Research Center, LLC
Anchorage, Alaska 99508
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Anchorage, AK
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San Diego Clinical Trials
6719 Alvarado Road
San Diego, California 92120
619-287-6000
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San Diego, CA
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Albany Medical College
47 New Scotland Ave
Albany, New York 12208
(518) 262-3125
Albany Medical College Albany Medical Center is northeastern New York's only academic health sciences center...
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Albany, NY
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Urology Group of New Mexico
Albuquerque, New Mexico 87109
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Albuquerque, NM
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Pacific Cancer Medical Center
Anaheim, California 92801
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Anaheim, CA
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Urologic Consultants of Southeaster PA LLP
1 Presidential Boulevard
Bala-Cynwyd, Pennsylvania 19004
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Bala-Cynwyd, PA
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Urology Center of Alabama PC
Birmingham, Alabama 35209
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Birmingham, AL
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Montefiore Medical Center PRIME
Bronx, New York 10467
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Bronx, NY
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Seattle Urology Research Center
Burien, Washington 98166
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Burien, WA
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Medical University of South Carolina
Charleston, South Carolina 29425
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Charleston, SC
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Erlanger Health System
Chattanooga, Tennessee 37403
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Chattanooga, TN
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The Carl and Edyth Lindner Center for Research and Education at the Christ Hospital
Cincinnati, Ohio 45219
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Cincinnati, OH
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Carolina Clinical Trials
Concord, North Carolina 28025
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Concord, NC
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Urology Clinics of North Texas
Dallas, Texas 75231
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Dallas, TX
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Signal Point Clinical Research Center
Dayton, Ohio 45409
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Dayton, OH
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Urology Center of Colorado
Denver, Colorado 80211
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Denver, CO
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Urology of Indiana
Greenwood, Indiana 46143
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Greenwood, IN
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First Urology PSC
Jeffersonville, Indiana 47130
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Jeffersonville, IN
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University of Kansas Medical Center Research Institute, Inc.
Kansas City, Kansas
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Kansas City, KS
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Kansas City VA Medical Center
Kansas City, Missouri 64128
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Kansas City, MO
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Okanagan Health Surgical Centre
Kelowna, British Columbia
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Kelowna,
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Comprehensive Urologic Care
Lake Barrington, Illinois
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Lake Barrington, IL
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Lancaster Urology
Lancaster, Pennsylvania 17604
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Lancaster, PA
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Premier Urology Associates
Lawrenceville, New Jersey
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Lawrenceville, NJ
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Kansas City Urology Care
Lenexa, Kansas 66214
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Lenexa, KS
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Clinical Trials Research
Lincoln, California 95648
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Lincoln, CA
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Urology Associates, PA
Little Rock, Arkansas 72211
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Little Rock, AR
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Tower Urology Medical Group
Los Angeles, California
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Los Angeles, CA
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San Marcus Research Clinic
Miami, Florida 33015
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Miami, FL
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Mount Sinai Comprehensive Cancer Center
Miami Beach, Florida 33140
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Miami Beach, FL
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Clinical Research Solutions, LLC
Middleburg Heights, Ohio 44130
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Middleburg Heights, OH
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Medical College of Wisconsin
8701 W Watertown Plank Rd
Milwaukee, Wisconsin
(414) 955-8296
Medical College of Wisconsin The Medical College (MCW) of Wisconsin is a major national research...
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Milwaukee, WI
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Delaware Valley Urology LLC Westhampton
Mount Laurel, New Jersey
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Mount Laurel, NJ
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Tulane University Health Sciences Center
1430 Tulane Ave Suite SL32
New Orleans, Louisiana 70112
(504) 588-5912
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Manhattan Medical Research Practice PLLC
New York, New York 10016
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New York, NY
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Memorial Sloan Kettering Cancer Center
1275 York Ave
New York, New York 10021
(212) 639-2000
Memorial Sloan Kettering Cancer Center Memorial Sloan Kettering Cancer Center — the world's oldest and...
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Premier Medical Group of the Hudson Valley PC
Newburgh, New York 12550
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Newburgh, NY
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Urology of Virginia
Norfolk, Virginia 23502
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Norfolk, VA
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University of Oklahoma Peggy and Charles Stephenson Cancer Center
Oklahoma City, Oklahoma 73104
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Oklahoma City, OK
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University of California, Irvine Medical Center
101 The City Drive South
Orange, California 92868
714-456-7890
University of California, Irvine Medical Center We are UC Irvine Health. We are a devoted...
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Orange, CA
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Clinical Research Center of Florida
Pompano Beach, Florida 33060
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Pompano Beach, FL
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Premier Medical Group
Poughkeepsie, New York 12601
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Poughkeepsie, NY
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Virginia Urology Center
Richmond, Virginia 23235
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Richmond, VA
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Veterans Affairs Medical Center-Salisbury, NC
Salisbury, North Carolina 28144
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Salisbury, NC
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Urology Associates of the Central Coast
San Luis Obispo, California 93401
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San Luis Obispo, CA
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University of Washington School of Medicine
Seattle, Washington 98195
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Seattle, WA
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Regional Urology
Shreveport, Louisiana 71106
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Shreveport, LA
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Springfield Clinic, LLP
Springfield, Illinois 62703
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Springfield, IL
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Oregon Urology Institute
Springfield, Oregon 97477
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Springfield, OR
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Madigan Army Medical Center
9040 Jackson Ave
Tacoma, Washington 98431
(253) 968-1110
Madigan Army Medical Center Located on Joint Base Lewis-McChord, Madigan Army Medical Center comprises a...
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Florida Urology Partners
Tampa, Florida 33607
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Tampa, FL
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Skyline Urology
Torrance, California 90505
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Torrance, CA
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Chesapeake Urology Associates
7505 Osler Drive
Towson, Maryland 21204
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Towson, MD
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Michigan Institute of Urology, P.C.
Troy, Michigan 48084
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Troy, MI
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Urological Associates of Southern Arizona, PC
Tucson, Arizona 85715
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Tucson, AZ
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Arizona Institute of Urology
Tucson, Arizona 85715
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Urologic Surgeons of Washington
Washington, District of Columbia 20036
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Washington,
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G. Patsias, M.D., PA
Wellington, Florida 33449
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Wellington, FL
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The Iowa Clinic
West Des Moines, Iowa 50266
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West Des Moines, IA
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Innovative Clinical Research Institute, LLC
Whittier, California 90603
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Whittier, CA
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PMG Research of Winston-Salem
1901 S Hawthorne Rd #306
Winston-Salem, North Carolina 27103
(336) 768-8062
PMG Research of Winston-Salem PMG Research of Winston-Salem, founded in 1979, occupies a 10,000 square...
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