Dilute Povidone-iodine Irrigation vs No Irrigation for Children With Acute, Perforated Appendicitis

Postoperative intra-abdominal abscesses are common occurrences after perforated appendicitis
in pediatric patients despite utilization of evidence-based practices. Povidone-iodine is a
commonly used antiseptic in surgical procedures and has been shown to be effective in
reducing postoperative abscesses in adults with perforated appendicitis. This trial will be
the first to rigorously test the efficacy of povidone-iodine irrigation in children and to
verify its safety profile in this patient population.

Inclusion Criteria:

- Children who undergo an appendectomy for perforated appendicitis. (Appendicitis:
Diagnosis is made intraoperatively by the surgeon. Diagnosis Method: The visualization
of a gross defect in the appendiceal wall or the presence of intraperitoneal stool or
a fecalith at the time of operation.)

Exclusion Criteria:

- Patients presenting with simple or gangrenous appendicitis

- Patients with a history of iodine sensitivity, thyroid disease or renal disease

- Patients undergoing interval or incidental appendectomy

- Patients/parents/legal guardians who are both non-English and non-Spanish speaking