Early Coronary Angiography Versus Delayed Coronary Angiography
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Cardiology, Hospital |
| Therapuetic Areas: | Cardiology / Vascular Diseases, Other |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 1/20/2019 |
| Start Date: | December 2015 |
| End Date: | April 30, 2019 |
A Pilot Randomized Clinical Trial of Early Coronary Angiography Versus No Early Coronary Angiography for Post-Cardiac Arrest Patients Without ECG ST Segment Elevation
This study is a pilot, multi-centered, randomized, clinical trial to evaluate the safety and
efficacy of performing early Coronary Angiography (CAG) versus no early CAG in post-cardiac
arrest patients without ST segment elevation. Safety will be assessed by evaluating the
association of major adverse events (re-arrest, bleeding, pulmonary edema, hypotension, acute
renal insufficiency, and pneumonia) with early coronary angiogram. Efficacy will be assessed
by a composite endpoint of improved left ventricular regional and global function (both
regional wall motion analysis and left ventricular ejection fraction) as measured by
echocardiography prior to hospital discharge and favourable neurological function (Cerebral
Performance Categories 1 or 2) at discharge.
efficacy of performing early Coronary Angiography (CAG) versus no early CAG in post-cardiac
arrest patients without ST segment elevation. Safety will be assessed by evaluating the
association of major adverse events (re-arrest, bleeding, pulmonary edema, hypotension, acute
renal insufficiency, and pneumonia) with early coronary angiogram. Efficacy will be assessed
by a composite endpoint of improved left ventricular regional and global function (both
regional wall motion analysis and left ventricular ejection fraction) as measured by
echocardiography prior to hospital discharge and favourable neurological function (Cerebral
Performance Categories 1 or 2) at discharge.
Cardiac arrest is a major public health issue. Arizona has been a leader in improving
long-term survival by introducing new and innovative resuscitation approaches including
"Chest Compression-Only CPR" and "Cardiocerebral Resuscitation". Post-resuscitation care is
the next great opportunity for further improvements. Early coronary angiography (CAG)
combined with therapeutic hypothermia has become the recommended standard of care for
post-cardiac arrest patients manifesting ST segment elevation on their electrocardiogram
(ECG). However, the majority of cardiac arrest victims do not have ST segment elevation.
There is clinical equipoise as to whether these patients will benefit from early CAG.
Subjects who are qualified for the study will be randomized 1:1 to one of two groups.
° Intervention Group-Early coronary angiography (door-to-angiography) within 120 minutes of
admission to Emergency Department.
or
° Control Group-No early coronary angiography (within the first six hours from admission)
All enrolled patients, will be treated with therapeutic hypothermia which is standard of
care, beginning simultaneously with both groups or within at least 2 hours of hospital
arrival.
Subject will be followed for 180 days for safety and long-term survival.
long-term survival by introducing new and innovative resuscitation approaches including
"Chest Compression-Only CPR" and "Cardiocerebral Resuscitation". Post-resuscitation care is
the next great opportunity for further improvements. Early coronary angiography (CAG)
combined with therapeutic hypothermia has become the recommended standard of care for
post-cardiac arrest patients manifesting ST segment elevation on their electrocardiogram
(ECG). However, the majority of cardiac arrest victims do not have ST segment elevation.
There is clinical equipoise as to whether these patients will benefit from early CAG.
Subjects who are qualified for the study will be randomized 1:1 to one of two groups.
° Intervention Group-Early coronary angiography (door-to-angiography) within 120 minutes of
admission to Emergency Department.
or
° Control Group-No early coronary angiography (within the first six hours from admission)
All enrolled patients, will be treated with therapeutic hypothermia which is standard of
care, beginning simultaneously with both groups or within at least 2 hours of hospital
arrival.
Subject will be followed for 180 days for safety and long-term survival.
Inclusion Criteria:
1. All successfully resuscitated out-of-hospital cardiac arrest patients with a suspected
cardiac etiology for their non-traumatic arrest
2. Age greater than 18 years
3. The post resuscitation ECG shows no evidence of ST segment elevation
Exclusion Criteria:
1. Non-resuscitated (no sustained pulse and BP)
2. Presence ST segment elevation or new left bundle branch block present on the
post-resuscitation ECG
3. Suspected non-cardiac etiology for their arrest such as respiratory failure, asphyxia,
pulmonary embolus, shock, trauma, drug overdose, or CNS bleed as likely cause of the
cardiac arrest
4. Known "Do Not Resuscitate" status
5. Minors (<18 years old)
6. Prisoners
7. Significant bleeding or blunt trauma
8. Known or confirmed pregnancy test by urinalysis
9. Patients who are known to have received any other investigational therapies within the
30 days prior to enrollment or during study duration will be excluded unless these
studies have been reviewed and approved by the Study Steering Committee.
10. Known "opt out" choice; wearing Opt-out band for any EFIC approved study or on an
"Opt-out" list
We found this trial at
5
sites
Click here to add this to my saved trials
Click here to add this to my saved trials
Click here to add this to my saved trials
Click here to add this to my saved trials
Click here to add this to my saved trials