Pharmacokinetics of MK-3682B in Participants With Moderate to Severe Renal Insufficiency

Inclusion Criteria:

All Participants:

- Healthy adult males or females 18-80 years of age at screening

- Continuous non-smokers or moderate smokers (≤ 20 cigarettes/day or the equivalent)
and agrees to consume no more than 10 cigarettes per day during the study period

- Body Mass Index (BMI) ≥ 18 and ≤ 40.0 kg/m2

- Agrees not to become pregnant or father a child during participation in the study

- Females of childbearing potential must either be abstinent for 14 days prior to
dosing and throughout the study or be using an acceptable birth control method

- Vasectomized or non-vasectomized males must agree to use a condom with spermicide or
abstain from sexual intercourse from the first dose until 90 days after dosing

- Males must agree not to donate sperm from dosing until 90 days after dosing

Moderate and Severe RI Participants:

- Baseline health is judged to be stable based on medical history, physical
examination, laboratory profiles, vital signs, or electrocardiograms (ECGs), as
deemed by the Investigator

- Has had no clinically significant change in renal status at least 1 month prior to
dosing and is not currently or has not previously been on hemodialysis

- Moderate RI: has baseline eGFR ≥ 30 mL/min/1.73m2 and < 60 mL/min/1.73m2, based on
the Modification of Diet in Renal Disease (MDRD) equation at screening

- Severe RI: has baseline eGFR ≥ 15 mL/min/1.73m2 and < 30 mL/min/1.73m2, based on the
MDRD equation at screening

Healthy Participants:

- Is within ± 10 years of the mean age of moderate and severe RI arms

- BMI is within 10% of the mean BMI of participants with moderate and severe RI arms

- Medically healthy with no clinically significant medical history, physical
examination, laboratory profiles, vital signs, or ECGs, as deemed by the Investigator

- Baseline CLcr ≥ 80 mL/min based on Cockcroft-Gault equation at screening

Exclusion Criteria:

- Is mentally or legally incapacitated or has significant emotional problems at the
time of the screening

- History or presence of clinically significant medical or psychiatric condition or
disease in the opinion of the Investigator

- History of any illness that, in the opinion of the Investigator, might confound the
results of the study or poses an additional risk by participating in the study

- Is female and pregnant or lactating

- Positive results for the urine or saliva drug screen or urine or breath alcohol
screen at screening or check-in unless the positive drug screen is due to
prescription drug use that is approved by the Investigator and Sponsor

- Positive results at screening for human immunodeficiency virus (HIV), hepatitis B
surface antigen (HBsAg), or hepatitis C virus (HCV)

- Seated heart rate is equal to or lower than 44 beats per minute (bpm) or higher than
100 bpm at screening

- Has had a renal transplant or has had nephrectomy

- Donation of blood or had significant blood loss within 56 days prior to dosing of
study drug, or donation of plasma within 7 days prior to dosing

- Has participated in another clinical trial within 28 days prior to dosing of study
drug