A Single-center Pilot Study Evaluating the Immediate Effects of Low-dose Acetazolamide on Respiratory Control in Subjects With Treatment Emergent Sleep Disordered Breathing



Status:Withdrawn
Conditions:Insomnia Sleep Studies
Therapuetic Areas:Psychiatry / Psychology
Healthy:No
Age Range:18 - 80
Updated:1/25/2017
Start Date:January 2016
End Date:March 2017

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Trial Summary
Trial Overview
Inclusion Criteria
This is a single center pilot study evaluating the immediate effects of low-dose
acetazolamide on respiratory control in subjects with treatment emergent sleep disordered
breathing. The purpose of this study is to assess the immediate effect one-time low-dose
acetazolamide on sleep breathing in (Treatment Emergent Sleep Disordered Breathing) TE-CSA
subjects compared to subjects' baseline evaluation without acetazolamide. Investigators will
also try to determine the immediate effect of one-time low-dose acetazolamide on subjects'
resting ventilation and ventilatory response slope compared to subjects' baseline evaluation
without acetazolamide.


Inclusion Criteria:

- Age ≥18 to 80 years

- TE-CSA

- Subjects are capable of giving informed consent

Exclusion Criteria:

- Hypersensitivity to acetazolamide or other sulfonamides

- Intake of carbonic anhydrase inhibitors within the last 72 hours

- Intake of medication that influences breathing, sleep, arousal or muscle physiology

- Cheyne-Stokes respiration

- Heart failure

- Renal failure

- Liver failure

- Chronic hypercapnea

- Hyponatremia

- Hypokalemia

- Pregnancy

- Breastfeeding mothers

- Active drug/alcohol dependence or abuse history
We found this trial at
1
site
New York University School of Medicine
550 1st Ave
New York, New York 10016
(212) 263-7300
Principal Investigator: David Rapoport, MD
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