Concurrent Bevacizumab With or Without Radiation Therapy in Treating Patients With Recurrent Glioblastoma
Status: | Recruiting |
---|---|
Conditions: | Brain Cancer, Brain Cancer |
Therapuetic Areas: | Oncology |
Healthy: | No |
Age Range: | 18 - Any |
Updated: | 4/21/2016 |
Start Date: | December 2012 |
Randomized Phase II Trial of Concurrent Bevacizumab and Re-irradiation Versus Bevacizumab Alone as Treatment for Recurrent Glioblastoma
This randomized phase II trial studies how well bevacizumab with or without radiation
therapy works in treating patients with glioblastoma that has returned after a period of
improvement. Monoclonal antibodies, such as bevacizumab, may block tumor growth by targeting
certain cells. Specialized radiation therapy that delivers a high dose of radiation directly
to the tumor may kill more tumor cells and cause less damage to normal tissue. It is not yet
known whether bevacizumab is more effective with or without radiation therapy in treating
patients with recurrent glioblastoma.
therapy works in treating patients with glioblastoma that has returned after a period of
improvement. Monoclonal antibodies, such as bevacizumab, may block tumor growth by targeting
certain cells. Specialized radiation therapy that delivers a high dose of radiation directly
to the tumor may kill more tumor cells and cause less damage to normal tissue. It is not yet
known whether bevacizumab is more effective with or without radiation therapy in treating
patients with recurrent glioblastoma.
PRIMARY OBJECTIVES:
I. To establish an improvement in overall survival in recurrent glioblastoma multiforme
(GBM) patients receiving bevacizumab and re-irradiation compared with patients receiving
bevacizumab alone.
SECONDARY OBJECTIVES:
I. To estimate and compare the rate of objective response in patients with measurable
disease.
II. To estimate and compare the 6-month progression-free survival rate. III. To estimate and
compare progression-free survival. IV. To estimate and compare the rate of treatment adverse
events. V. To estimate and compare the rate of >= grade 3 acute or delayed central nervous
system (CNS) toxicity.
OUTLINE: Patients are randomized to 1 of 2 treatment arms.
ARM I: Patients receive bevacizumab intravenously (IV) over 30-90 minutes every 2 weeks.
ARM II: Patients receive bevacizumab as in Arm I and undergo radiation therapy using
intensity-modulated radiation therapy (IMRT), 3-dimensional conformal radiation therapy
(3D-CRT), or proton beam radiation therapy (RT) 5 days a week for 2 weeks.
In both arms, courses with bevacizumab repeat every 2 weeks in the absence of disease
progression or unacceptable toxicity.
After completion of study treatment, patients are followed up every 2 months for 1 year,
every 6 months for 1 year and then annually thereafter.
I. To establish an improvement in overall survival in recurrent glioblastoma multiforme
(GBM) patients receiving bevacizumab and re-irradiation compared with patients receiving
bevacizumab alone.
SECONDARY OBJECTIVES:
I. To estimate and compare the rate of objective response in patients with measurable
disease.
II. To estimate and compare the 6-month progression-free survival rate. III. To estimate and
compare progression-free survival. IV. To estimate and compare the rate of treatment adverse
events. V. To estimate and compare the rate of >= grade 3 acute or delayed central nervous
system (CNS) toxicity.
OUTLINE: Patients are randomized to 1 of 2 treatment arms.
ARM I: Patients receive bevacizumab intravenously (IV) over 30-90 minutes every 2 weeks.
ARM II: Patients receive bevacizumab as in Arm I and undergo radiation therapy using
intensity-modulated radiation therapy (IMRT), 3-dimensional conformal radiation therapy
(3D-CRT), or proton beam radiation therapy (RT) 5 days a week for 2 weeks.
In both arms, courses with bevacizumab repeat every 2 weeks in the absence of disease
progression or unacceptable toxicity.
After completion of study treatment, patients are followed up every 2 months for 1 year,
every 6 months for 1 year and then annually thereafter.
Inclusion Criteria:
- Histopathologically proven diagnosis of glioblastoma or variants (gliosarcoma, giant
cell glioblastoma etc); patients will be eligible if the original histology was
lower-grade glioma and a subsequent diagnosis of glioblastoma or gliosarcoma is made
- Patients who did not have recent surgery for their glioblastoma must have shown
unequivocal radiographic evidence for tumor progression by contrast-enhanced MRI
scan (or CT scan for patients with non-compatible devices) within 21 days prior
to registration; Note: patients who did have surgery with a post-operative
contrast-enhanced scan falling outside the 5-week window prior to registration,
per definition of recent surgery, must have a repeat magnetic resonance imaging
(MRI) scan (or computed tomography [CT] scan for patients with non-compatible
devices) within 21 days prior to registration
- Patients must have passed an interval of 6 months or greater between completion
of prior radiotherapy and registration; if patients have not passed an interval
of at least 6 months, they may still be eligible if they meet one or more of the
following criteria:
- New areas of tumor outside the original radiotherapy fields as determined
by the investigator, or
- Histologic confirmation of tumor through biopsy or resection, or
- Nuclear medicine imaging, magnetic resonance (MR) spectroscopy, or MR
perfusion imaging consistent with true progressive disease, rather than
radiation necrosis obtained within 28 days of registration AND an interval
of at least 90 days between completion of radiotherapy and registration
- Patients unable to undergo MR imaging because of non-compatible devices can be
enrolled provided CT scans are obtained and are of sufficient quality; patients
without non-compatible devices may not use CT scans performed to meet this
requirement
- Prior history of standard dose CNS radiation of 60 Gy in 30 fractions or 59.4 Gy in
1.8 Gy fractions, or equivalent or lower doses
- Patients who have received prior treatment with non-standard radiation therapy
(RT) dose and fractionation, interstitial brachytherapy, stereotactic
radiosurgery, etc. are eligible as long as the criterion is met or approved by a
principal investigator
- Patients must have recovered from the toxic effects of prior therapy, and there must
be a minimum time of 28 days prior to registration from the administration of any
investigational agent or prior cytotoxic therapy with the following exceptions:
- 14 days from administration of vincristine
- 42 days from administration of nitrosoureas
- 21 days from administration of procarbazine
- Patients having undergone recent resection of their glioblastoma (within 5 weeks
prior to registration) must have recovered from the effects of surgery; for CNS
related core or needle biopsies, a minimum of 7 days must have elapsed prior to
registration
- Residual disease following resection of recurrent glioblastoma is not mandated
for eligibility into the study; to best assess the extent of residual disease
post-operatively, a post-operative or intra-operative MRI scan (or CT scan for
patients with non-compatible devices) must be performed prior to registration
and should be within 96 hours post surgery (although 24 hours would be optimum)
- History/physical examination, including neurologic examination, within 14 days prior
to registration
- Karnofsky performance status >= 60 within 14 days prior to registration
- Complete blood count (CBC)/differential obtained within 14 days prior to
registration, with adequate bone marrow function
- Absolute neutrophil count (ANC) >= 1,500 cells/mm^3
- Platelets >= 75,000 cells/mm^3
- Hemoglobin >= 9.0 g/dl (Note: the use of transfusion or other intervention to achieve
hemoglobin [Hgb] >= 9.0 g/dl is acceptable)
- Total bilirubin =< 2.0 mg/dL
- Serum glutamic oxaloacetic transaminase (SGOT) or aspartate aminotransferase (AST) =<
2.5 times the upper limit of normal
- Serum creatinine =< 1.8 mg/dL
- Urine protein: creatinine (UPC) ratio < 1.0 within 14 days prior to registration OR
urine dipstick for proteinuria =< 2 positive (+) (patients discovered to have > 2+
proteinuria on dipstick urinalysis at baseline must have a UPC ratio done that is <
1.0 to be eligible; if the UPC ratio is >= 1.0 then the patients should undergo a
24-hour urine collection and must demonstrate =< 1g of protein in 24 hours to be
eligible)
- Note: UPC ratio of spot urine is an estimation of the 24-hour urine protein
excretion; a UPC ratio of 1 is roughly equivalent to a 24-hour urine protein of
1 gm
- Patients must not be pregnant (positive pregnancy test) or breast feeding; pregnancy
test must be done within 7 days prior to registration; effective contraception (men
and women) must be used in patients of child-bearing potential while on study
treatment and for 6 months after
- Patients on full-dose anticoagulants (e.g., warfarin or low molecular weight [LMW]
heparin) must meet both of the following criteria:
- No active bleeding or pathological condition that carries a high risk of
bleeding (e.g., tumor involving major vessels or known varices)
- In-range international normalized ratio (INR) (usually between 2 and 3) on a
stable dose of oral anticoagulant or on a stable dose of low molecular weight
heparin, within 14 days prior to registration
- Patient must be able to provide study-specific informed consent prior to study entry
Exclusion Criteria:
- More than three relapses
- Infratentorial, or leptomeningeal evidence of recurrent disease
- Recurrent or persistent tumor greater than 6 cm in maximum diameter
- Prior therapy with an inhibitor of vascular endothelial growth factor (VEGF) or VEGF
receptor (VEGFR) (including bevacizumab)
- Prior invasive malignancy (except non-melanomatous skin cancer) unless disease free
for a minimum of 1 year (for example, carcinoma in situ of the breast, oral cavity,
or cervix are all permissible)
- Severe, active co-morbidity, defined as follows:
- Unstable angina and/or congestive heart failure requiring hospitalization within
the last 6 months prior to registration
- Transmural myocardial infarction within the last 6 months prior to registration
- History of stroke or transient ischemic attack within 6 months prior to
registration
- Significant vascular disease (e.g., aortic aneurysm, history of aortic
dissection) or clinically significant peripheral vascular disease
- Acute bacterial or fungal infection requiring intravenous antibiotics at the
time of registration
- Chronic obstructive pulmonary disease exacerbation or other respiratory illness
requiring hospitalization or precluding study therapy at the time of
registration
- Hepatic insufficiency resulting in clinical jaundice and/or coagulation defects;
note, however, that laboratory tests for liver function other than screening
panel and coagulation parameters are not required for entry into this protocol
- Acquired immune deficiency syndrome (AIDS) based upon current Centers for
Disease Control and Prevention (CDC) definition; note, however, that human
immunodeficiency virus (HIV) testing is not required for entry into this
protocol; the need to exclude patients with AIDS from this protocol is necessary
because the treatments involved in this protocol may be significantly
immunosuppressive; protocol specific requirements may also exclude
immuno-compromised patients
- Pregnancy or women of childbearing potential and men who are sexually active and not
willing/able to use medically acceptable forms of contraception
- Prior allergic reaction to the study drug (bevacizumab)
- Prior history of hypertensive crisis or hypertensive encephalopathy
- History of a non-healing wound, ulcer, or bone fracture within 90 days (3 months)
prior to registration
- Gastrointestinal bleeding or any other hemorrhage/bleeding event Common Terminology
Criteria for adverse Events (CTCAE), v. 4 grade 3 or greater within 30 days prior to
registration
- Major surgical procedure, open biopsy, or significant traumatic injury within 28 days
prior to registration (with the exception of craniotomy)
We found this trial at
193
sites
295 Varnum Ave
Lowell, Massachusetts 01854
Lowell, Massachusetts 01854
(978) 937-6000
Principal Investigator: Matthew S. Katz
Phone: 978-788-7084
Lowell General Hospital Welcome to Lowell General Hospital! Our goal is to provide you with...
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800 Washington St
Boston, Massachusetts 02111
Boston, Massachusetts 02111
(617) 636-5000
Principal Investigator: John E. Mignano
Phone: 617-636-5000
Tufts Medical Center Tufts Medical Center is an internationally-respected academic medical center – a teaching...
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Brigham and Women's Hosp Boston’s Brigham and Women’s Hospital (BWH) is an international leader in...
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3300 Gallows Road
Falls Church, Virginia 22042
Falls Church, Virginia 22042
(703) 776-4001
Principal Investigator: Samir P. Kanani
Phone: 703-208-6650
Inova Fairfax Hospital Inova Fairfax Hospital, Inova's flagship hospital, is an 833-bed, nationally recognized regional...
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301 University Blvd
Galveston, Texas 77555
Galveston, Texas 77555
(409) 772-1011
Principal Investigator: Martin Colman
Phone: 409-772-1950
University of Texas Medical Branch Established in 1891 as the University of Texas Medical Department,...
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2500 N State St
Jackson, Mississippi 39216
Jackson, Mississippi 39216
(601) 984-1000
Principal Investigator: Mark D. Anderson
Phone: 601-815-6700
University of Mississippi Medical Center The University of Mississippi Medical Center, located in Jackson, is...
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200 North Park Street
Kalamazoo, Michigan 49007
Kalamazoo, Michigan 49007
(269) 382-2500
Principal Investigator: Sunil Nagpal
Phone: 269-373-7458
West Michigan Cancer Center In 1994, Borgess Health Alliance and Bronson Healthcare Group opened the...
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UMDNJ-New Jersey Medical School NJMS is committed to educating humanistic, culturally competent physicians who will...
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4805 Northeast Glisan Street
Portland, Oregon 97213
Portland, Oregon 97213
(503) 215-1111
Principal Investigator: Matthew C. Solhjem
Phone: 503-215-6412
Providence Portland Medical Center We strive to give those we serve exceptional, compassionate health care...
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401 College Street
Richmond, Virginia 23298
Richmond, Virginia 23298
(804) 828-0450
Principal Investigator: Douglas W. Arthur
Phone: 804-628-1939
Virginia Commonwealth University Massey Cancer Center Founded in 1974, VCU Massey Cancer Center is a...
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60 Crittenden Blvd # 70
Rochester, New York 14642
Rochester, New York 14642
(585) 275-2121
Principal Investigator: Yuhchyau Chen
Phone: 585-275-5830
University of Rochester The University of Rochester is one of the country's top-tier research universities....
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808 North 39th Avenue
Yakima, Washington 98902
Yakima, Washington 98902
Principal Investigator: Sean F. Cleary
Phone: 877-902-3324
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Akron, Ohio 44304
Principal Investigator: Desiree E. Doncals
Phone: 330-375-6101
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1 Akron General Ave
Akron, Ohio 44307
Akron, Ohio 44307
(330) 344-6000
Principal Investigator: Mitchel L. Fromm
Phone: 330-344-6348
Akron General Medical Center It
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5301 McAuley Drive
Ann Arbor, Michigan 48197
Ann Arbor, Michigan 48197
734-712-3456
Principal Investigator: Samir Narayan
Phone: 734-712-4673
Saint Joseph Mercy Hospital St. Joseph Mercy Ann Arbor Hospital is a 537-bed teaching hospital...
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1500 East Medical Center Drive
Ann Arbor, Michigan 48109
Ann Arbor, Michigan 48109
800-865-1125
Principal Investigator: Christina I. Tsien
Phone: 734-936-4307
University of Michigan Comprehensive Cancer Center The U-M Comprehensive Cancer Center's mission is the conquest...
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Annapolis, Maryland 21401
Principal Investigator: Peter R. Graze
Phone: 443-481-1320
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550 Peachtree St NE
Atlanta, Georgia 30308
Atlanta, Georgia 30308
(404) 686-4411
Principal Investigator: Ian R. Crocker
Phone: 404-778-1868
Emory University Hospital Midtown Emory University Hospital Midtown is a 511-bed community-based, acute care teaching...
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Atlanta, Georgia 30322
Principal Investigator: Ian R. Crocker
Phone: 404-778-1868
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1968 Peachtree Rd NW
Atlanta, Georgia 30309
Atlanta, Georgia 30309
(404) 605-5000
Principal Investigator: Adam W. Nowlan
Phone: 404-425-7943
Piedmont Hospital For more than a century, Piedmont Healthcare has been a recognized leader in...
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1000 Johnson Ferry Rd NE
Atlanta, Georgia 30342
Atlanta, Georgia 30342
(404) 851-8000
Principal Investigator: Sahar E. Rosenbaum
Phone: 404-303-3355
Northside Hospital Northside Hospital-Atlanta (in Sandy Springs) opened in 1970. The original facility had 250...
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Auburn, California 95603
Principal Investigator: Ari D. Baron
Phone: 415-209-2686
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Austin, Texas 78701
Principal Investigator: Mateo Ziu
Phone: 512-324-7991
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22 South Greene Street
Baltimore, Maryland 21201
Baltimore, Maryland 21201
410-328-7904
Principal Investigator: Young Kwok
Phone: 800-888-8823
University of Maryland Greenebaum Cancer Center The University of Maryland Marlene and Stewart Greenebaum Cancer...
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155 5th St NE
Barberton, Ohio 44203
Barberton, Ohio 44203
(330) 615-3000
Principal Investigator: Desiree E. Doncals
Phone: 330-375-6101
Summa Barberton Hospital Summa Barberton Hospital is a full member of Summa Health System and...
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Bay Shore, New York 11706
Principal Investigator: Jonathan P. Knisely
Phone: 516-562-3467
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Beaver, Pennsylvania 15009
Principal Investigator: John C. Flickinger
Phone: 412-647-2811
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Bel Air, Maryland 21014
Principal Investigator: Young Kwok
Phone: 800-888-8823
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1300 Anne Street NW
Bemidji, Minnesota 56601
Bemidji, Minnesota 56601
(218) 751-5430
Principal Investigator: Preston D. Steen
Phone: 701-234-6161
Sanford Clinic North-Bemidgi Sanford Health is a voluntary, not-for-profit health care organization. Through its entities,...
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Berlin, Vermont 05602
Principal Investigator: Carl J. Nelson
Phone: 802-656-4101
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Bethlehem, Pennsylvania 18015
Principal Investigator: Nimisha Deb
Phone: 610-954-3582
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Billings, Montana 59101
Principal Investigator: Benjamin T. Marchello
Phone: 800-648-6274
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Birmingham, Alabama 35233
Principal Investigator: John B. Fiveash
Phone: 205-934-0309
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300 N. Seventh St.
Bismarck, North Dakota 58501
Bismarck, North Dakota 58501
(701) 323-6000
Principal Investigator: Preston D. Steen
Phone: 701-234-6161
Sanford Bismarck Medical Center Whether your stay in our hospital is one day for same...
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Boise, Idaho 83706
Principal Investigator: Samir Narayan
Phone: 734-712-4673
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55 Fruit St
Boston, Massachusetts 02114
Boston, Massachusetts 02114
(617) 724-4000
Principal Investigator: Kevin S. Oh
Phone: 877-726-5130
Massachusetts General Hospital Cancer Center An integral part of one of the world
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Dana-Farber Cancer Institute Since it’s founding in 1947, Dana-Farber has been committed to providing adults...
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Boulder, Colorado 80303
Principal Investigator: Keren Sturtz
Phone: 888-785-6789
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Bridgeport, Connecticut 06606
Principal Investigator: Nicholas A. Blondin
Phone: 203-576-6329
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Bronx, New York 10467
Principal Investigator: Mary R. Welch
Phone: 718-904-2730
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Burbank, California
Principal Investigator: Matthew C. Solhjem
Phone: 503-215-6412
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Burlington, Massachusetts 01805
Principal Investigator: Brian J. Scott
Phone: 781-744-8027
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Burlington, Vermont 05405
Principal Investigator: Steven P. Emmons
Phone: 802-656-8990
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Cameron Park, California 95682
Principal Investigator: Ari D. Baron
Phone: 415-209-2686
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171 Ashley Avenue
Charleston, South Carolina 29425
Charleston, South Carolina 29425
843-792-1414
Principal Investigator: Scott M. Lindhorst
Phone: 843-792-9321
Medical University of South Carolina The Medical University of South Carolina (MUSC) has grown from...
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Charlotte, North Carolina 28204
Principal Investigator: Ashley L. Sumrall
Phone: 843-958-2665
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303 East Superior Street
Chicago, Illinois 60611
Chicago, Illinois 60611
Principal Investigator: Jeffrey J. Raizer
Phone: 312-695-1301
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1969 W Ogden Ave
Chicago, Illinois 60612
Chicago, Illinois 60612
(312) 864-6000
Principal Investigator: Thomas E. Lad
Phone: 312-864-6000
John H. Stroger, Jr. Hospital of Cook County The Level 1 Trauma Center is one...
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1200 West Harrison Stree
Chicago, Illinois 60607
Chicago, Illinois 60607
(312) 996-4350
Principal Investigator: Matthew Koshy
Phone: 312-355-3046
Univ of Illinois A major research university in the heart of one of the world's...
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5841 S Maryland Ave
Chicago, Illinois 60637
Chicago, Illinois 60637
1-773-702-6180
Principal Investigator: Steven J. Chmura
Phone: 773-834-7424
University of Chicago Comprehensive Cancer Center The University of Chicago Comprehensive Cancer Center (UCCCC) is...
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9280 SE Sunnybrook Blvd #100
Clackamas, Oregon 97015
Clackamas, Oregon 97015
(503) 513-3300
Principal Investigator: Matthew C. Solhjem
Phone: 503-215-6412
Clackamas Radiation Oncology Center State-of-the-art technology and compassionate care come together at Clackamas Radiation Oncology...
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10900 Euclid Ave
Cleveland, Ohio 44106
Cleveland, Ohio 44106
216-368-2000
Principal Investigator: Simon S. Lo
Phone: 800-641-2422
Case Western Reserve Univ Continually ranked among America's best colleges, Case Western Reserve University has...
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6001 E Woodmen Rd
Colorado Springs, Colorado 80923
Colorado Springs, Colorado 80923
(719) 776-5000
Principal Investigator: Keren Sturtz
Phone: 888-785-6789
Penrose-Saint Francis Healthcare Founded by the Sisters of St. Francis and the Sisters of Charity,...
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Colorado Springs, Colorado 80903
Principal Investigator: Brian D. Kavanagh
Phone: 720-848-0650
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3535 Olentangy River Rd
Columbus, Ohio 43214
Columbus, Ohio 43214
(614) 566-5000
Principal Investigator: John P. Kuebler
Phone: 614-566-3275
Riverside Methodist Hospital Serving central Ohio since 1892, Riverside Methodist Hospital is consistently ranked one...
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Cumming, Georgia 30041
Principal Investigator: Sahar E. Rosenbaum
Phone: 404-303-3355
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100 North Academy Avenue
Danville, Pennsylvania 17822
Danville, Pennsylvania 17822
570-271-6211
Principal Investigator: Thomas J. Gergel
Phone: 570-271-5251
Geisinger Medical Center Since 1915, Geisinger Medical Center has been known as the region’s resource...
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Deerfield Beach, Florida 33442
Principal Investigator: Fazilat Ishkanian
Phone: 866-574-5124
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22101 Moross Rd
Detroit, Michigan 48236
Detroit, Michigan 48236
(313) 343-4000
Principal Investigator: Samir Narayan
Phone: 734-712-4673
Saint John Hospital and Medical Center Founded in 1952, St. John Hospital and Medical Center...
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Dublin, California 94568
Principal Investigator: James H. Feusner
Phone: 510-450-7600
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820 4th St N
Fargo, North Dakota 58102
Fargo, North Dakota 58102
(701) 234-6161
Principal Investigator: Preston D. Steen
Phone: 701-234-6161
Roger Maris Cancer Center Sanford Health is an integrated health system headquartered in the Dakotas...
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1024 S Lemay Ave
Fort Collins, Colorado 80524
Fort Collins, Colorado 80524
(970) 495-7000
Principal Investigator: Brian D. Kavanagh
Phone: 720-848-0650
Poudre Valley Hospital A 270-bed regional medical center offering a wide array of treatments, surgeries,...
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Fort Wayne, Indiana 46804
Principal Investigator: Brian K. Chang
Phone: 260-373-8888
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2200 Randallia Drive
Fort Wayne, Indiana 46805
Fort Wayne, Indiana 46805
Principal Investigator: Brian K. Chang
Phone: 260-373-8888
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Fresno, California 93720
Principal Investigator: Samantha A. Seaward
Phone: 626-564-3455
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Gastonia, North Carolina 28054
Principal Investigator: Charles J. Meakin
Phone: 704-834-2932
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835 S Van Buren St
Green Bay, Wisconsin 54301
Green Bay, Wisconsin 54301
(920) 433-0111
Principal Investigator: Gregory M. Cooley
Phone: 920-433-8889
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1726 Shawano Ave
Green Bay, Wisconsin 54303
Green Bay, Wisconsin 54303
(920) 498-4200
Principal Investigator: Gregory M. Cooley
Phone: 920-433-8889
Saint Mary's Hospital Our team of dedicated physicians, nurses and staff offer a broad spectrum...
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501 N. Elam Avenue
Greensboro, North Carolina 27403
Greensboro, North Carolina 27403
336-832-1100
Principal Investigator: Matthew A. Manning
Phone: 336-832-0821
Cone Health Cancer Center Located adjacent to Wesley Long Hospital, our Cone Health Cancer Center...
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Greensburg, Pennsylvania 15601
Principal Investigator: John C. Flickinger
Phone: 412-647-2811
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Greenville, South Carolina 29605
Principal Investigator: David L. Grisell
Phone: 864-241-6251
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Greenville, South Carolina 29615
Principal Investigator: David L. Grisell
Phone: 864-241-6251
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Greer, South Carolina 29650
Principal Investigator: David L. Grisell
Phone: 864-241-6251
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Greer, South Carolina 29651
Principal Investigator: Patricia C. Griffin
Phone: 800-486-5941
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Henderson, Nevada 89052
Principal Investigator: John A. Ellerton
Phone: 702-384-0013
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500 University Dr
Hershey, Pennsylvania 17033
Hershey, Pennsylvania 17033
(717) 531-6955
Principal Investigator: Henry Wagner
Phone: 717-531-3779
Penn State Milton S. Hershey Medical Center Penn State Milton S. Hershey Medical Center, Penn...
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1301 Punchbowl St
Honolulu, Hawaii 96813
Honolulu, Hawaii 96813
(808) 538-9011
Principal Investigator: Paul A. DeMare
Phone: 808-545-8548
Queen's Medical Center The Queen's Medical Center, located in downtown Honolulu, Hawaii, is a private,...
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Indianapolis, Indiana 46202
Principal Investigator: Mark P. Langer
Phone: 317-274-2552
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Jacksonville, Florida
Principal Investigator: Mark E. Augspurger
Phone: 904-202-7051
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Joliet, Illinois 60435
Principal Investigator: Kulumani M. Sivarajan
Phone: 815-730-3098
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4401 Wornall Rd
Kansas City, Missouri 64111
Kansas City, Missouri 64111
(816) 932-2000
Principal Investigator: Rakesh Gaur
Phone: 816-932-2677
Saint Luke's Hospital, Kansas City Saint Luke's Hospital is a not-for-profit tertiary referral center committed...
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2316 E Meyer Blvd
Kansas City, Missouri 64132
Kansas City, Missouri 64132
(816) 276-4000
Principal Investigator: Rakesh Gaur
Phone: 816-932-2677
Research Medical Center Research Medical Center offers hospital and health clinic services across three Kansas...
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8700 N. Green Hills Road
Kansas City, Missouri 64154
Kansas City, Missouri 64154
816.746.4570
Kansas City Cancer Centers - North Through world-class research and patient care, The University of...
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Kennewick, Washington 99336
Principal Investigator: George E. Laramore
Phone: 206-616-8289
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3535 Southern Blvd
Kettering, Ohio 45429
Kettering, Ohio 45429
(937) 298-4331
Principal Investigator: Howard M. Gross
Phone: 937-775-1350
Kettering Medical Center Our flagship hospital, Kettering Medical Center, stands proudly in Kettering, Ohio. From...
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Knoxville, Tennessee 37920
Principal Investigator: Marcio A. Fagundes
Phone: 865-244-3209
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1915 White Ave.
Knoxville, Tennessee 37916
Knoxville, Tennessee 37916
(865) 541-1678
Principal Investigator: Daniel D. Scaperoth
Phone: 865-541-1812
Thompson Cancer Survival Center The Thompson Cancer Survival Center Downtown facility has pioneered many advances...
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La Crosse, Wisconsin
Principal Investigator: Collin D. Driscoll
Phone: 608-775-2385
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3855 Health Sciences Dr,
La Jolla, California 92093
La Jolla, California 92093
(858) 822-6100
UC San Diego Moores Cancer Center Established in 1978, UC San Diego Moores Cancer Center...
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Lancaster General Hospital For more than a century, Lancaster General Hospital has been a leader...
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Las Vegas, Nevada 89128
Principal Investigator: John A. Ellerton
Phone: 702-384-0013
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Las Vegas, Nevada 89144
Principal Investigator: John A. Ellerton
Phone: 702-384-0013
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Las Vegas, Nevada 89169
Principal Investigator: John A. Ellerton
Phone: 702-384-0013
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9280 W. Sunset Road
Suite 100
Las Vegas, Nevada 89148
Las Vegas, Nevada 89148
702.952.1251
Principal Investigator: John A. Ellerton
Phone: 702-384-0013
Comprehensive Cancer Centers of Nevada Comprehensive Cancer Centers of Nevada (CCCN) is the award-winning multidisciplinary...
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