An Investigational Immuno-therapy Study of Experimental Medication BMS-986156, Given by Itself or in Combination With Nivolumab in Patients With Solid Cancers or Cancers That Have Spread.
Status: | Active, not recruiting |
---|---|
Conditions: | Cancer |
Therapuetic Areas: | Oncology |
Healthy: | No |
Age Range: | 18 - Any |
Updated: | 2/2/2019 |
Start Date: | October 9, 2015 |
End Date: | May 28, 2020 |
A Phase 1/2a Dose Escalation and Cohort Expansion Study for Safety, Tolerability, and Efficacy of BMS-986156 Administered Alone and in Combination With Nivolumab (BMS-936558, Anti PD-1 Monoclonal Antibody) in Advanced Solid Tumors
The purpose of this study is to evaluate the safety and tumor-shrinking ability of
experimental medication BMS-986156, when given by itself or in combination with nivolumab in
patients with solid cancers that are advanced or cancers that have spread.
experimental medication BMS-986156, when given by itself or in combination with nivolumab in
patients with solid cancers that are advanced or cancers that have spread.
For more information regarding BMS clinical trial participation, please visit
www.BMSStudyConnect.com
Inclusion Criteria:
- For Dose Escalation:
- Subjects with any previously treated advanced (metastatic or refractory) solid
tumor
- For Cohort Expansion:
- Subjects must have a previously treated advanced solid tumor to be eligible
- Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1
- Willing and able to provide pre-treatment and on-treatment fresh tumor biopsy
- Women of child-bearing potential and men must use an acceptable method of
contraception during treatment and for 23 weeks after treatment for women and 31 weeks
for men
Exclusion Criteria:
- Known central nervous system metastases or central nervous system as the only source
of disease
- Other concomitant malignancies (with some exceptions per protocol)
- Active, known or suspected autoimmune disease
- Uncontrolled or significant cardiovascular disease
- History of active or chronic hepatitis (e.g. Hep B or C)
- Impaired liver or bone marrow function
- Major surgery less than 1 month before start of the study
We found this trial at
8
sites
Emory University Emory University, recognized internationally for its outstanding liberal artscolleges, graduate and professional schools,...
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1720 2nd Ave S
Birmingham, Alabama 35233
Birmingham, Alabama 35233
(205) 934-4011
![University of Alabama at Birmingham](/wp-content/uploads/logos/university-of-alabama-at-birmingham.jpg)
Phone: 205-975-7265
University of Alabama at Birmingham The University of Alabama at Birmingham (UAB) traces its roots...
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4805 Northeast Glisan Street
Portland, Oregon 97213
Portland, Oregon 97213
(503) 215-1111
![Providence Portland Medical Center](/wp-content/uploads/logos/providence-portland-medical-center.png)
Phone: 503-215-7715
Providence Portland Medical Center We strive to give those we serve exceptional, compassionate health care...
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Ohio State University The Ohio State University’s main Columbus campus is one of America’s largest...
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111 S 11th St
Philadelphia, Pennsylvania 19107
Philadelphia, Pennsylvania 19107
(215) 955-6000
![Thomas Jefferson University Hospital](/wp-content/uploads/logos/thomas-jefferson-university-hospital.png)
Phone: 215-503-9096
Thomas Jefferson University Hospital Our hospitals in Center City Philadelphia share a 13-acre campus with...
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