Treatment of Impulsive Aggression in Subjects With ADHD in Conjunction With Standard ADHD Treatment (CHIME 2)

Inclusion Criteria:

- Otherwise healthy male or female subjects, age 6 to 12 years at the time of screening
with a primary diagnosis of ADHD and currently receiving monotherapy treatment with
an optimized FDA-approved ADHD medication.

- Impulsive aggression will be confirmed at screening using R-MOAS and Vitiello
Aggression Scale.

Exclusion Criteria:

- Current or lifetime diagnosis of epilepsy, major depressive disorder, bipolar
disorder, schizophrenia or related disorder, personality disorder, Tourette's
disorder, or psychosis not otherwise specified.

- Currently meeting DSM criteria for autism spectrum disorder, pervasive developmental
disorder, obsessive compulsive disorder, post-traumatic stress disorder, or any other
anxiety disorder as primary diagnosis.

- Known or suspected intelligence quotient (IQ) < 70, suicidality, pregnancy, or
substance or alcohol abuse.