Optimizing Chronic Pain Treatment With Enhanced Neuroplastic Responsiveness
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Arthritis, Chronic Pain, Osteoarthritis (OA) |
| Therapuetic Areas: | Musculoskeletal, Rheumatology |
| Healthy: | No |
| Age Range: | 50 - 85 |
| Updated: | 12/30/2018 |
| Start Date: | February 2016 |
| End Date: | September 2019 |
The purpose of the study is to identify non-invasive strategies that will optimize the
neurobiological environment and improve learning and memory in the treatment of chronic pain.
The overall aims of the current proposal are to determine if food restriction and/or glucose
administration in conjunction with a relaxation/guided imagery exercise will result in
neurophysiological changes and functional improvements compared to the relaxation/guided
imagery exercise alone.
neurobiological environment and improve learning and memory in the treatment of chronic pain.
The overall aims of the current proposal are to determine if food restriction and/or glucose
administration in conjunction with a relaxation/guided imagery exercise will result in
neurophysiological changes and functional improvements compared to the relaxation/guided
imagery exercise alone.
Up to sixty adults with chronic knee pain with or/at risk of knee osteoarthritis will be
randomized to one of three groups: food restriction (20 participants), glucose administration
(20 participants), or control (20 participants). Participants will attend four sessions over
a two to three week period.
randomized to one of three groups: food restriction (20 participants), glucose administration
(20 participants), or control (20 participants). Participants will attend four sessions over
a two to three week period.
Inclusion Criteria:
- Adults with chronic knee pain with or/at risk of knee osteoarthritis
Exclusion Criteria:
- Concurrent medical condition that could confound outcome measures or limit the ability
to participate completely in the protocol including: neurological conditions
(Parkinson's disease, multiple sclerosis, and/or seizures)
- History of a head injury or stroke
- Diabetes or taking medications to control blood sugar
- Mental health issues resulting in hospitalization or outpatient treatment in the past
year, and/or psychotropic medication use
- Current issue or history of treatment for alcohol or other substance abuse
- Cognitive function < or = 22 on the Mini-Mental Status Exam
- Pregnancy
- A baseline fasting blood sugar (plasma glucose > 7mmol/L) or persisting blood pressure
>150/95.
- Heart condition such as a prior heart attack, heart surgery (including a stent),
frequent chest pain or heart failure
- Inability to complete the EEG portion of the study
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