MRI-Guided Stereotactic Body Radiation Therapy in Treating Patients With Liver Metastases or Liver Cancer

PRIMARY OBJECTIVES:

I. To assess the feasibility of utilizing an MRI-guided tri-60Co teletherapy system for
liver SBRT, as determined the treating radiation oncologist's ability to accurately
visualize and align to the target lesion(s).

II. To assess the feasibility of using a three versus five fraction scheme, for one versus
multiple (i.e., =< 5) target lesions.

SECONDARY OBJECTIVES:

I. To determine the tumor local control (LC), disease specific survival (DSS), and overall
survival (OS).

II. To gather biomarkers that may elucidate differential immunogenic responses from the
three versus the five fraction SBRT regimens.

OUTLINE:

Patients undergo MRI-guided Tri-60Co teletherapy SBRT 3-5 fractions over 1-2 weeks.

After completion of study treatment, patients are followed up at approximately 4-6 weeks,
and then every 3 months for 2 years.

Inclusion Criteria:

- Patients may have either metastatic lesions from another primary site or primary
hepatocellular carcinoma; patients with one histologically confirmed metastatic
lesion of the liver who are presenting for local therapy for lesions concerning for
metastases that cannot or should not be biopsied will also be considered for
enrollment on a case by case basis; patients can simultaneously receive treatment for
multiple hepatic lesions meeting the prior two requirements, at the discretion of the
treating radiation oncologist

- Karnofsky performance status (KPS) >= 70

- No active infections requiring systemic antibiotics

- If a woman is of childbearing potential, a negative urine or serum pregnancy test
must be documented; women of childbearing potential must agree to use adequate
contraception (hormonal or barrier method of birth control; or abstinence) for
duration of study participation and for up to 4 weeks following the study

- Ability to understand and willingness to sign a written informed consent

Exclusion Criteria:

- Pregnant women, or women of childbearing potential who are sexually active and not
willing/able to use medically acceptable forms of contraception for the entire study
period and for up to 4 weeks after the study

- Refusal to sign the informed consent

- Patients who are participating in a concurrent treatment protocol

- Patients for whom a plan meeting institutional quality criteria cannot be designed
for SBRT treatment via the MRI-guided teletherapy unit, but for whom an SBRT plan
meeting institutional quality criteria can be designed for a conventional linear
accelerator