Pneumonia in the Intensive Care Unit (ICU) Setting
| Status: | Completed |
|---|---|
| Conditions: | Pneumonia, Pulmonary |
| Therapuetic Areas: | Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 5/10/2018 |
| Start Date: | January 2016 |
| End Date: | February 1, 2017 |
The purpose of this observational study is to collect prospective data on the occurrence of
bacterial and viral pneumonia in the ICU setting. Current classification systems for
pneumonia promote over treatment with antibiotics as they do not specifically recognize the
presence of culture-negative and viral pneumonia. The investigators will collect data to
determine if a novel pneumonia classification system can be developed that more accurately
links the etiology of pneumonia (antibiotic-susceptible bacterial pneumonia,
antibiotic-resistant bacterial pneumonia, culture-negative pneumonia, viral pneumonia) to
clinical outcomes. Additionally, the investigators will collect data on the practice of
antimicrobial stewardship in the ICU setting to determine if further improvements in
antibiotic practices can be accomplished in the future.
bacterial and viral pneumonia in the ICU setting. Current classification systems for
pneumonia promote over treatment with antibiotics as they do not specifically recognize the
presence of culture-negative and viral pneumonia. The investigators will collect data to
determine if a novel pneumonia classification system can be developed that more accurately
links the etiology of pneumonia (antibiotic-susceptible bacterial pneumonia,
antibiotic-resistant bacterial pneumonia, culture-negative pneumonia, viral pneumonia) to
clinical outcomes. Additionally, the investigators will collect data on the practice of
antimicrobial stewardship in the ICU setting to determine if further improvements in
antibiotic practices can be accomplished in the future.
The investigators will be prospectively collecting data on patients admitted to the 8300 and
8400 medical intensive care units at Barnes-Jewish Hospital requiring invasive mechanical
ventilation for support in respiratory failure from pneumonia. Data will be collected on
patients admitted from 1/2016-12/2016. The investigators will be collecting initial patient
characteristic data as well as reviewing microbial specimen results (tracheal aspirate,
bronchial alveolar lavage, viral multiplex, blood cultures) and antibiotic usage in real
time. The investigators will identify any changes in antibiotic usage demonstrated with the
advising of the ICU antibiotic stewardship team.
8400 medical intensive care units at Barnes-Jewish Hospital requiring invasive mechanical
ventilation for support in respiratory failure from pneumonia. Data will be collected on
patients admitted from 1/2016-12/2016. The investigators will be collecting initial patient
characteristic data as well as reviewing microbial specimen results (tracheal aspirate,
bronchial alveolar lavage, viral multiplex, blood cultures) and antibiotic usage in real
time. The investigators will identify any changes in antibiotic usage demonstrated with the
advising of the ICU antibiotic stewardship team.
Inclusion Criteria:
- age 18+, admitted for 8300 or 8400 medical ICU between 1/2016 and 12/2016 for
respiratory failure from pneumonia, requirement of > 24 hours of invasive mechanical
ventilatory support for pneumonia
Exclusion Criteria:
- Immunocompromised as defined by HIV/AIDS, known immunodeficiency, chronic steroids >
20mg/day Prednisone equivalent, other home immunosuppressants, solid organ or bone
marrow transplant patients, cystic fibrosis, bronchiectasis, active malignancy,
receiving chemotherapy or radiation therapy within the past 3 months, hematologic
malignancy
- Chronic ventilator dependence
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