Appendectomy Versus Non-Operative Treatment For Acute Non-Perforated Appendicitis in Children
| Status: | Recruiting |
|---|---|
| Conditions: | Gastrointestinal |
| Therapuetic Areas: | Gastroenterology |
| Healthy: | No |
| Age Range: | 5 - 16 |
| Updated: | 1/11/2019 |
| Start Date: | January 2016 |
| End Date: | January 2020 |
| Contact: | Shawn D St. Peter, MD |
| Email: | sspeter@cmh.edu |
| Phone: | 816-234-3575 |
A Multicentre, Randomized Controlled Trial Comparing Appendectomy Versus Non-Operative Treatment For Acute Non-Perforated Appendicitis in Children
Rationale and Aim: The standard treatment for acute appendicitis in children is appendectomy.
An increasing body of evidence from the adult literature suggests that acute appendicitis may
be treated effectively with antibiotics alone, avoiding the need for surgery. The aim of this
study is to investigate the effectiveness of non-operative treatment of acute appendicitis in
children.
Study design: Pragmatic, parallel-group, unmasked, non-inferiority multicentre randomized
controlled trial (RCT).
Patient allocation: Children will be randomly allocated (age 5-16 years) with a diagnosis of
acute appendicitis to either laparoscopic appendectomy or treatment with antibiotics.
Randomization will be performed using stratification to ensure equal distribution between
groups of presenting clinical and demographic features that may influence outcome including
gender, duration of symptoms and center.
Interventions: One group of children will undergo laparoscopic appendectomy that is the
current standard treatment for children with acute appendicitis. The other group will be
treated with intravenous antibiotics. A treatment pathway specifically designed for this
study will be used.
Primary Outcome: To be meaningful to parents of, and clinicians treating, children with acute
appendicitis, the primary outcome is treatment failure defined as: (i) any additional
intervention related to appendicitis requiring general anesthesia within 1 year of
randomization (including recurrence of appendicitis after non-operative treatment, which we
will treat with appendectomy) or (ii) negative appendectomy. Secondary outcomes are: (i)
complications; (ii) time to discharge following randomization; (iii) number and duration of
hospital admissions.
Sample size and data analysis: The proposed RCT has a 20% non-inferiority margin to test the
null hypothesis that treatment with antibiotics is inferior to appendectomy. Based on data
from collaborating centers and a pilot study that we have performed, we expect recruitment of
978 children in total (90% power) over 19 months allowing for drop out. Follow-up will be for
12 months.
An increasing body of evidence from the adult literature suggests that acute appendicitis may
be treated effectively with antibiotics alone, avoiding the need for surgery. The aim of this
study is to investigate the effectiveness of non-operative treatment of acute appendicitis in
children.
Study design: Pragmatic, parallel-group, unmasked, non-inferiority multicentre randomized
controlled trial (RCT).
Patient allocation: Children will be randomly allocated (age 5-16 years) with a diagnosis of
acute appendicitis to either laparoscopic appendectomy or treatment with antibiotics.
Randomization will be performed using stratification to ensure equal distribution between
groups of presenting clinical and demographic features that may influence outcome including
gender, duration of symptoms and center.
Interventions: One group of children will undergo laparoscopic appendectomy that is the
current standard treatment for children with acute appendicitis. The other group will be
treated with intravenous antibiotics. A treatment pathway specifically designed for this
study will be used.
Primary Outcome: To be meaningful to parents of, and clinicians treating, children with acute
appendicitis, the primary outcome is treatment failure defined as: (i) any additional
intervention related to appendicitis requiring general anesthesia within 1 year of
randomization (including recurrence of appendicitis after non-operative treatment, which we
will treat with appendectomy) or (ii) negative appendectomy. Secondary outcomes are: (i)
complications; (ii) time to discharge following randomization; (iii) number and duration of
hospital admissions.
Sample size and data analysis: The proposed RCT has a 20% non-inferiority margin to test the
null hypothesis that treatment with antibiotics is inferior to appendectomy. Based on data
from collaborating centers and a pilot study that we have performed, we expect recruitment of
978 children in total (90% power) over 19 months allowing for drop out. Follow-up will be for
12 months.
Background Acute appendicitis is the commonest surgical emergency in children. The lifetime
risk of developing appendicitis is 7-8%, with a peak incidence in the teenage years.The
associated financial burden of treating appendicitis is very large.
For over 100 years, surgical removal of the appendix has been deemed necessary to effectively
treat acute appendicitis. Appendectomy remains the cornerstone of treatment for acute
appendicitis, with the exception of phlegmon or appendix mass. However, in recent years this
surgical dogma has been challenged and there is a growing literature to suggest that
antibiotics without surgery may be an effective treatment for acute appendicitis in adults
and more recently in children. However this non-operative management of acute appendicitis
remains controversial and unproven due to the lack of large prospective randomized controlled
trials.
Although appendectomy is generally a simple procedure, it requires general anesthesia and is
an abdominal operation with inherent risks and potential complications. Complications related
to surgery or anesthesia events occur in over 10% of children within 30 days of appendectomy.
Although a non-operative approach may avoid these risks and reduce complication rate, this
would not be a viable alternative to surgery unless it is equally effective at curing acute
appendicitis.
The existing literature relating to the efficacy of non-operative treatment of acute
appendicitis in predominantly from adult patients. Several trials and systematic reviews have
been reported. A most recent meta-analysis concluded that there were benefits to
non-operative treatment including fewer complications, better pain control, and shorter sick
leave but that the combined failure and recurrence rate in patients treated non-operatively
made this approach less effective overall.
In children, the literature is limited. The most significant studies are: Abes et al [6] who
described successful, non-operative treatment in 15 of 16 children who had a very short
duration of illness, and minimal diagnostic criteria on imaging; Armstrong et al [7] who
reported a 75% success rate in 12 children treated non-operatively along with a matched
comparison group undergoing surgery; two RCTs from the USA that compared appendectomy with
antibiotic treatment for children with perforated appendicitis [8,9] (a different patient
group from the one which we intend to study); a single centre, preference-based,
non-randomized study comparing laparoscopic appendectomy with antibiotic treatment [10] that
reported interim results only.
In preparation for this multi center RCT, investigators have performed a pilot RCT at one of
the participating centers (Karolinska Institute, Stockholm) [11]. Successfully demonstrated
feasibility of recruitment to a RCT and safety of non-operative treatment of children with
acute appendicitis.
Based on these observations, and in response to parents who are now asking whether their
child with acute appendicitis really needs an operation, this randomized controlled trial
comparing appendectomy with non-operative treatment in children with acute appendicitis will
be done. The principal research question is: Can children with acute uncomplicated
(non-perforated) appendicitis be treated without appendectomy?
Rationale for the Trial This trial has the potential to significantly alter clinical practice
for one of the most common acute health conditions in children. A finding of non-inferiority
of treatment with antibiotics compared to appendectomy would be transformative for the
healthcare of children with acute appendicitis in Canada and abroad, including low- and
middle-income countries. Reducing the need for surgery in the treatment of childhood
appendicitis represents the potential for cost savings for the healthcare system, and will
enable improved access for children with non-emergent conditions who are awaiting surgery.
Methods/Design Research question Can children with acute non-perforated appendicitis be
treated with antibiotics, rather than appendectomy?
Trial design The APPY trial has been designed as a pragmatic, parallel-group, unmasked,
non-inferiority multicentre, international randomized controlled trial. The protocol has been
developed in accordance with the SPIRIT guideline and the trial will be conducted and
reported according to the CONSORT statement.
Participants Children (5-16 years of age) with suspected acute uncomplicated appendicitis
will be enrolled from up to 16 hospitals across Europe and North America. All centers are
specialist Pediatric Surgery Referral Centers with trained Specialist Pediatric Surgeons and
Pediatric Surgery Training Programs. All children with suspected acute non-perforated
appendicitis will be assessed by the on-call surgeon who will determine eligibility for the
study. This will be based on a clinical and/or ultrasound diagnosis of acute non-perforated
appendicitis. The patient and child will be informed of the trial and invited to participate.
Randomization After signed informed consent, a standardized data set will be collected from
all participants at all participating institutions. Patients enrolled in the study will be
randomized to groups (1:1 ratio) using an online stratified randomization tool, allowing
instant assignment to treatment group 24 hours per day with concealment of allocation.
Allocation to groups will be stratified taking into account factors that may affect outcome
of treatment: 1) Sex: Male; Female; 2) Duration of symptoms <48hrs; >48hrs; and 3) Center.
Interventions Patients will be allocated to non-operative antibiotic treatment or
appendectomy.
Non-operative treatment group: Participants allocated to non-operative treatment will be
treated according to a treatment pathway standardized across all centers comprising
intravenous fluid treatment, a minimum of 12 hours of intravenous antibiotics, a minimum
period of 12 hours taking clear fluid only, and regular clinical review.
During the next clinical rounds, or alternatively approximately 12 hours after randomization,
a review of clinical symptoms will be conducted to detect symptoms and signs of significant
clinical deterioration including, but not limited to, increased fever, increased tachycardia,
and increased pain or tenderness. If the patient is doing well, they may be advanced to
regular diet and be assessed for discharge during the same work day, depending on their
clinical progression. If they are stable without deterioration but not improved to the point
of discharge they will continue with non-operative management. A patient who has not improved
after 48 hours of non-operative management will undergo appendectomy. All decisions will be
made by the treating physicians and care team with consideration of the input of parents and
child where appropriate.
Children in whom non-operative treatment is successful will receive a minimum of 12 hours
intravenous antibiotics and then be switched to oral antibiotics once they have shown
clinical improvement. They will be discharged home once they meet a standardized set of
criteria to be used in all centers: vital signs (including temperature) within normal limits,
tolerating a light diet orally, adequate oral pain relief and mobile. They will receive a
total course of 10 days of antibiotics (intravenous and oral) following randomization.
Children within the non-operative treatment group will remain under the care of an attending
pediatric surgeon who retains overall responsibility for their care. If a child's clinical
condition deteriorates at any time, they will undergo laparoscopic appendectomy, and will
receive post-operative care identical to that of children in the appendectomy treatment group
(see below), and any other care that might be dictated by sound clinical judgement.
The choice of antibiotics will vary between center and will be the antibiotic regimen that is
current standard of care in that center. This is due to (i) varying antibiotic regimes among
participating centers at present influenced by local factors, including antimicrobial
stewardship and drug cost (26) and (ii) a lack of evidence to support a specific antibiotic
regimen for childhood appendicitis. Allowing each center to maintain current antibiotic
protocols will improve study feasibility and increase generalizability of the results.
However, the duration of combined intravenous and oral therapy will be standardized to 10
days.
Following discharge, children who receive non-operative treatment will not be offered
elective appendectomy. They will be counselled about the risk of recurrence as part of the
permission process for the trial using best available current data. Recurrence of
appendicitis within the 1 year follow-up period will be treated with appendectomy; these
children will not be eligible for re-enrollment.
Appendectomy group: Children allocated to appendectomy will undergo laparoscopic appendectomy
within approximately 18 hours of randomization which is the current standard of care in all
centers participating in this study. Participants will receive intravenous antibiotics from
the time of randomization and be treated post-operatively with intravenous antibiotics
according to a defined and standardized treatment regime based on consensus for this trial.
Specifically, children with a macroscopically normal appendix or non-perforated acute
appendicitis will receive no further antibiotics. Children with perforated appendicitis will
continue to receive intravenous antibiotics for a minimum of 3 days, and may receive
additional antibiotics per local practice. The type of antibiotics used in each center will
be identical to those used in the non-operative treatment group. Following cessation of
intravenous antibiotics, criteria for discharge home will be identical to those in the
non-operative treatment group.
risk of developing appendicitis is 7-8%, with a peak incidence in the teenage years.The
associated financial burden of treating appendicitis is very large.
For over 100 years, surgical removal of the appendix has been deemed necessary to effectively
treat acute appendicitis. Appendectomy remains the cornerstone of treatment for acute
appendicitis, with the exception of phlegmon or appendix mass. However, in recent years this
surgical dogma has been challenged and there is a growing literature to suggest that
antibiotics without surgery may be an effective treatment for acute appendicitis in adults
and more recently in children. However this non-operative management of acute appendicitis
remains controversial and unproven due to the lack of large prospective randomized controlled
trials.
Although appendectomy is generally a simple procedure, it requires general anesthesia and is
an abdominal operation with inherent risks and potential complications. Complications related
to surgery or anesthesia events occur in over 10% of children within 30 days of appendectomy.
Although a non-operative approach may avoid these risks and reduce complication rate, this
would not be a viable alternative to surgery unless it is equally effective at curing acute
appendicitis.
The existing literature relating to the efficacy of non-operative treatment of acute
appendicitis in predominantly from adult patients. Several trials and systematic reviews have
been reported. A most recent meta-analysis concluded that there were benefits to
non-operative treatment including fewer complications, better pain control, and shorter sick
leave but that the combined failure and recurrence rate in patients treated non-operatively
made this approach less effective overall.
In children, the literature is limited. The most significant studies are: Abes et al [6] who
described successful, non-operative treatment in 15 of 16 children who had a very short
duration of illness, and minimal diagnostic criteria on imaging; Armstrong et al [7] who
reported a 75% success rate in 12 children treated non-operatively along with a matched
comparison group undergoing surgery; two RCTs from the USA that compared appendectomy with
antibiotic treatment for children with perforated appendicitis [8,9] (a different patient
group from the one which we intend to study); a single centre, preference-based,
non-randomized study comparing laparoscopic appendectomy with antibiotic treatment [10] that
reported interim results only.
In preparation for this multi center RCT, investigators have performed a pilot RCT at one of
the participating centers (Karolinska Institute, Stockholm) [11]. Successfully demonstrated
feasibility of recruitment to a RCT and safety of non-operative treatment of children with
acute appendicitis.
Based on these observations, and in response to parents who are now asking whether their
child with acute appendicitis really needs an operation, this randomized controlled trial
comparing appendectomy with non-operative treatment in children with acute appendicitis will
be done. The principal research question is: Can children with acute uncomplicated
(non-perforated) appendicitis be treated without appendectomy?
Rationale for the Trial This trial has the potential to significantly alter clinical practice
for one of the most common acute health conditions in children. A finding of non-inferiority
of treatment with antibiotics compared to appendectomy would be transformative for the
healthcare of children with acute appendicitis in Canada and abroad, including low- and
middle-income countries. Reducing the need for surgery in the treatment of childhood
appendicitis represents the potential for cost savings for the healthcare system, and will
enable improved access for children with non-emergent conditions who are awaiting surgery.
Methods/Design Research question Can children with acute non-perforated appendicitis be
treated with antibiotics, rather than appendectomy?
Trial design The APPY trial has been designed as a pragmatic, parallel-group, unmasked,
non-inferiority multicentre, international randomized controlled trial. The protocol has been
developed in accordance with the SPIRIT guideline and the trial will be conducted and
reported according to the CONSORT statement.
Participants Children (5-16 years of age) with suspected acute uncomplicated appendicitis
will be enrolled from up to 16 hospitals across Europe and North America. All centers are
specialist Pediatric Surgery Referral Centers with trained Specialist Pediatric Surgeons and
Pediatric Surgery Training Programs. All children with suspected acute non-perforated
appendicitis will be assessed by the on-call surgeon who will determine eligibility for the
study. This will be based on a clinical and/or ultrasound diagnosis of acute non-perforated
appendicitis. The patient and child will be informed of the trial and invited to participate.
Randomization After signed informed consent, a standardized data set will be collected from
all participants at all participating institutions. Patients enrolled in the study will be
randomized to groups (1:1 ratio) using an online stratified randomization tool, allowing
instant assignment to treatment group 24 hours per day with concealment of allocation.
Allocation to groups will be stratified taking into account factors that may affect outcome
of treatment: 1) Sex: Male; Female; 2) Duration of symptoms <48hrs; >48hrs; and 3) Center.
Interventions Patients will be allocated to non-operative antibiotic treatment or
appendectomy.
Non-operative treatment group: Participants allocated to non-operative treatment will be
treated according to a treatment pathway standardized across all centers comprising
intravenous fluid treatment, a minimum of 12 hours of intravenous antibiotics, a minimum
period of 12 hours taking clear fluid only, and regular clinical review.
During the next clinical rounds, or alternatively approximately 12 hours after randomization,
a review of clinical symptoms will be conducted to detect symptoms and signs of significant
clinical deterioration including, but not limited to, increased fever, increased tachycardia,
and increased pain or tenderness. If the patient is doing well, they may be advanced to
regular diet and be assessed for discharge during the same work day, depending on their
clinical progression. If they are stable without deterioration but not improved to the point
of discharge they will continue with non-operative management. A patient who has not improved
after 48 hours of non-operative management will undergo appendectomy. All decisions will be
made by the treating physicians and care team with consideration of the input of parents and
child where appropriate.
Children in whom non-operative treatment is successful will receive a minimum of 12 hours
intravenous antibiotics and then be switched to oral antibiotics once they have shown
clinical improvement. They will be discharged home once they meet a standardized set of
criteria to be used in all centers: vital signs (including temperature) within normal limits,
tolerating a light diet orally, adequate oral pain relief and mobile. They will receive a
total course of 10 days of antibiotics (intravenous and oral) following randomization.
Children within the non-operative treatment group will remain under the care of an attending
pediatric surgeon who retains overall responsibility for their care. If a child's clinical
condition deteriorates at any time, they will undergo laparoscopic appendectomy, and will
receive post-operative care identical to that of children in the appendectomy treatment group
(see below), and any other care that might be dictated by sound clinical judgement.
The choice of antibiotics will vary between center and will be the antibiotic regimen that is
current standard of care in that center. This is due to (i) varying antibiotic regimes among
participating centers at present influenced by local factors, including antimicrobial
stewardship and drug cost (26) and (ii) a lack of evidence to support a specific antibiotic
regimen for childhood appendicitis. Allowing each center to maintain current antibiotic
protocols will improve study feasibility and increase generalizability of the results.
However, the duration of combined intravenous and oral therapy will be standardized to 10
days.
Following discharge, children who receive non-operative treatment will not be offered
elective appendectomy. They will be counselled about the risk of recurrence as part of the
permission process for the trial using best available current data. Recurrence of
appendicitis within the 1 year follow-up period will be treated with appendectomy; these
children will not be eligible for re-enrollment.
Appendectomy group: Children allocated to appendectomy will undergo laparoscopic appendectomy
within approximately 18 hours of randomization which is the current standard of care in all
centers participating in this study. Participants will receive intravenous antibiotics from
the time of randomization and be treated post-operatively with intravenous antibiotics
according to a defined and standardized treatment regime based on consensus for this trial.
Specifically, children with a macroscopically normal appendix or non-perforated acute
appendicitis will receive no further antibiotics. Children with perforated appendicitis will
continue to receive intravenous antibiotics for a minimum of 3 days, and may receive
additional antibiotics per local practice. The type of antibiotics used in each center will
be identical to those used in the non-operative treatment group. Following cessation of
intravenous antibiotics, criteria for discharge home will be identical to those in the
non-operative treatment group.
Inclusion criteria
- children (age 5-16 years)
- clinical and /or radiological diagnosis (ultrasound [US] and/or CT scan) of acute
non-perforated appendicitis
- written informed parental/legal guardian permission in accordance with local
regulations and institutional policy
- written informed child assent or waiver in accordance with local regulations and
institutional policy
Exclusion criteria
- suspicion of perforated appendicitis
- presentation with an appendix mass or phlegmon (on physical examination and/or
imaging)
- non-operative management (2 or more rounds of intravenous antibiotics) initiated at an
outside institution
- previous episode of appendicitis or appendix mass/phlegmon treated non-operatively
- current treatment for malignancy
- positive pregnancy test (if part of a clinical routine)
- diagnosis of Cystic Fibrosis (CF)
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