Leptospermum Scoparium Honey and Wound Care for Pressure Ulcers

The investigators hypothesize that the use of leptospermum scoparium honey as a type of
dressing and/or debridement agent on stage III or IV pressure ulcers has an increased
efficacy and safety compared to the current treatment protocol that includes the use of
hydrogel/Vaseline, collagenase, and silver alginate dressings as the standard of care.
Utilizing a non-inferiority trial, it is expected that the use of leptospermum scoparium as
a treatment for Stage III and Stage IV pressure ulcers will not be inferior to the
comparison treatment of standard of care wound dressings. Moreover, this research design
will enable the research team to determine if the honey based dressings are equivalent to or
superior to the comparison treatment.

Therefore, the investigators specific study objectives are as follows:

1. Primary Objectives: Determine if the use of honey as an alternative treatment will
reduce site inflammation/irritation and pain associated with pressure ulcers compared
to the standard treatment options. Specifically, the investigators will monitor patient
PUSH scores, Braden Risk Scale scores, granulation and/or epithelial tissue
progression, length of time to heal, patient pain assessments via the Wong Baker Face
or Numeric Scale, wound odors, and incidence of adverse events (measured by allergies,
stinging sensations, bacterial infections that warrant antibiotic intervention, etc.).

2. Secondary Objective: Patients in the honey treatment group will have lower costs per
healed ulcer than patients in the standard collagenase treatment group.