Gut Permeability Assessment in Celiac and Gluten Sensitive Children
| Status: | Completed |
|---|---|
| Conditions: | Endocrine |
| Therapuetic Areas: | Endocrinology |
| Healthy: | No |
| Age Range: | 2 - 17 |
| Updated: | 8/17/2018 |
| Start Date: | March 2016 |
| End Date: | August 1, 2018 |
The Role of Gut Permeability in Developing Celiac Disease and Non-Celiac Gluten Sensitivity
This study will assess the effect of gluten on gut barrier function. Investigators at the
Mayo Clinic have developed a new gut permeability test using rhamnose (sugar & water
solution), and are hoping to prove its effectiveness in a clinical setting.
Mayo Clinic have developed a new gut permeability test using rhamnose (sugar & water
solution), and are hoping to prove its effectiveness in a clinical setting.
The aim of this study is to assess effect of gluten on the gut barrier function in patients
at high risk for celiac disease and non-celiac gluten sensitivity (NCGS) patients. This study
will assess the gut permeability in three groups of patients 1) children who are at high risk
for developing celiac disease (CD) (siblings of patients with celiac disease), 2) Children
who are self-diagnosed with NCGS and 3) control group of patients matched for age and gender.
Patients will undergo celiac serologic and genetic testing, after which the rhamnose test
will be performed to assess the presence of increased gut permeability.
at high risk for celiac disease and non-celiac gluten sensitivity (NCGS) patients. This study
will assess the gut permeability in three groups of patients 1) children who are at high risk
for developing celiac disease (CD) (siblings of patients with celiac disease), 2) Children
who are self-diagnosed with NCGS and 3) control group of patients matched for age and gender.
Patients will undergo celiac serologic and genetic testing, after which the rhamnose test
will be performed to assess the presence of increased gut permeability.
High Risk group:
- Sibling with a confirmed diagnosis of celiac disease
- No history Celiac disease or any other bowel disease
Non-Celiac Gluten Sensitivity group:
- Self-diagnosis of gluten sensitivity
- No history of celiac disease or other bowel disease
Healthy group:
- Absence of celiac disease or any other bowel disease
- No sensitivity to gluten
We found this trial at
1
site
200 First Street SW
Rochester, Minnesota 55905
Rochester, Minnesota 55905
507-284-2511
Principal Investigator: Imad Absah, MD
Mayo Clinic Rochester Mayo Clinic is a nonprofit worldwide leader in medical care, research and...
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