Genioglossus Strength and OSAS

To describe by statistical analysis the normal distribution domain of genioglossus muscle
strength in each of the four clinical stages of Sleep Apnea; and, by regression analysis, to
explore the possibility of an inverse relationship between decreasing genioglossus strength
and progression of the clinical stages of OSAS.

1.3. To test the hypothesis that a "subpopulation of subject" exists within the clinical
spectrum of OSAS, in whom decreasing strength of the genioglossus muscle may represent a
common element in spite of differing possible pathophysiologic pathways leading to
Obstructive Sleep Apnea in man. 1.4. The major hypothesis of this proposal is thus that
"Genioglossal Strength is inversely correlated with Obstructive Sleep Apnea Pathology."

Inclusion Criteria:

- Age 20-40 years inclusive BMI 18-25 Non-smoking history and no current use for a
minimum of 6 months No smokeless tobacco products (including e-cigarettes) for a
minimum of 6 months No sleep snoring reported by subject and by bedroom "companion"
Self-described as active/athletic (i.e. regular hikes, walks, jogging, running, active
Sports, such as volleyball, soccer, etc.) Self-described as healthy, with no known
disease or recent illness Self-completed Epworth Sleepiness Scale of <6 (Johns, MW, A
new method for Measuring daytime sleepiness: the Epworth Sleepiness Scale; SLEEP
14:450-5, 1991). Physical Examination Mallampati Score of Class 1 (Nuckton, TJ, et al:
Physical

Examination: Mallampati Score as an Independent Predictor of OSAS; SLEEP 29:

903-908, 2006).

Exclusion Criteria: