IVIG in Patients With VGKC Ab Associated Autoimmune Epilepsy

The purpose of this study is to determine if intravenous immunoglobulin (IVIG) treatment
significantly reduces the number of epileptic seizures in cases of autoimmune epilepsy.
Potential participants will be screened at an outpatient neurology clinic visit appointment.
Interested qualified potential participants will be consented and offered participation in
this trial. Once consent has been obtained, and it is determined that the participant meets
all inclusion criteria, the participant will be randomized to either IVIG or placebo
treatment for the next 5 weeks. Participants will return to Mayo Clinic for an evaluation.
Those participants that received the placebo for 5 weeks will be given IVIG in an open label
fashion for 5 weeks (week 7-11) then return to Mayo Clinic for evaluation. All participants
will receive monthly phone calls after they complete the IVIG treatment for a period of 1
year from the end of IVIG 5 week course.

Inclusion Criteria:

- Seropositivity for Voltage Gated Potassium Channel Complex (VGKC) complex antibodies
or positive for Leucine-Rich, Glioma Inactivated 1 (LGI1)/contactin-associated
protein-like 2 (CASPR2) Antibody by cell based assay.

- And ≥ 2 seizures per week (mean of total over 1 week)

- And duration of epilepsy <3 years

- Male or female between the ages of 18 and 80 years of age

- Women and men of child bearing potential must agree to use a reliable form of
contraception throughout the course of the study.

- Homecare treatment agency available at place of residence.

Exclusion Criteria:

- History of thrombotic episodes within the 2 years prior to enrollment

- Known allergic or other severe reactions to blood products including intolerability to
previous IVIG

- Immunoglobulin A (IgA) deficiency

- Prior failed trial of high dose steroid (prednisone >60mg daily or methylprednisolone
>1g weekly for >2 weeks)

- Reproductive status:

- Women who are pregnant,

- Women who are breastfeeding,

- Women and men of childbearing potential who are unwilling or unable to use an
acceptable method of birth control to avoid pregnancy for the entire study
period, as evaluated by the investigator. (Women of non-childbearing potential
are those that have a history of hysterectomy, bilateral oophorectomy, or are
postmenopausal with no history of menstrual flow for > 12 months prior to screen
visit.)

- Any surgical procedure (except for minor surgeries) within 4 weeks prior to baseline.

- Evidence of serious uncontrolled concomitant diseases that may preclude patient
participation (physician determined), as described; Other nervous system disease,
cardiovascular disease, hematologic/hematopoiesis disease, respiratory disease,
muscular disease, endocrine disease, renal/urologic disease, digestive system disease,
congenital or acquired severe immunodeficiency

- Known active infection (excluding fungal infections of nail beds or caries dentium)
within 4 weeks prior to baseline.

- Evidence of chronic active hepatitis B or C.

- Active ischemic heart disease in the past year prior to baseline.

- Patients should not have severe renal or hepatic disease (determined by treating
physician).

- Severe hypertension