Hemodialysis-based Interventions to Preserve Cognitive Function

This will be a pilot, single center, randomized, controlled trial to slow cognitive decline
in adults undergoing hemodialysis (HD). The investigators primary objective is to demonstrate
feasibility for the interventions (cognitive training and exercise training) in Aim 1. The
investigators will formally test whether whether cognitive training (tablet-based brain
games) and exercise training (stationary foot pedal) administered during HD slow cognitive
decline as well as improve secondary outcomes (physical function, frailty, and health-related
quality of life (HRQOL) as part of Aim 2. The investigators will compare these two
interventions against the standard of care. Pre- and post-intervention assessments will be
conducted at the dialysis unit by a study coordinator and by research assistants.
Participants will be followed for 6 months to assess cognitive decline.

Inclusion Criteria:

- Men and women with end stage renal disease and receiving hemodialysis at the DaVita
Dialysis Centers located at 409 N. Caroline St., Baltimore, MD will be approached by
our study coordinator to determine eligibility.

- Must be at least 18 years or older at enrollment

- Must be English speaking

- Must be willing to participate in research and able to give informed consent

Exclusion Criteria:

- Chronic lung disease requiring oxygen

- Cerebrovascular disease

- Musculoskeletal conditions that limit mobility

- Lower or upper extremity amputation

- Orthopedic disorders exacerbated by physical activity

- Decreased mental capacity

- Dementia (diagnosed)