Mitochondrial Function in Circulating Cells and Muscle Tissue
| Status: | Completed |
|---|---|
| Conditions: | Healthy Studies, Obesity Weight Loss, Endocrine |
| Therapuetic Areas: | Endocrinology, Other |
| Healthy: | No |
| Age Range: | 25 - 35 |
| Updated: | 6/27/2018 |
| Start Date: | September 2016 |
| End Date: | May 1, 2018 |
The main goal of this project is to determine whether mitochondrial function in circulating
cells is related to that measured in the muscle fibers of the same subjects.
cells is related to that measured in the muscle fibers of the same subjects.
Data from human and animal models strongly suggests that reduced tissue mitochondrial
function can be an early marker for detection of dysfunctional metabolism. It is unclear if
tissue mitochondrial dysfunction can be detected using less invasive methodology. In this
project, the investigators plan to study mitochondrial bioenergetics in circulating cells and
paired muscle biopsies in two metabolic disparate groups of women; healthy lean vs. obese
insulin resistant women of similar age. Women of similar age that are either healthy lean or
insulin resistant and obese will be recruited to participate in one study that includes a
blood draw and a muscle biopsy. Mitochondrial function in circulating blood cells and muscle
tissue will be determined.
function can be an early marker for detection of dysfunctional metabolism. It is unclear if
tissue mitochondrial dysfunction can be detected using less invasive methodology. In this
project, the investigators plan to study mitochondrial bioenergetics in circulating cells and
paired muscle biopsies in two metabolic disparate groups of women; healthy lean vs. obese
insulin resistant women of similar age. Women of similar age that are either healthy lean or
insulin resistant and obese will be recruited to participate in one study that includes a
blood draw and a muscle biopsy. Mitochondrial function in circulating blood cells and muscle
tissue will be determined.
Inclusion Criteria:
- Women
- 25-35 years of age
- Either healthy lean (BMI<25) or insulin resistant and obese (BMI >30)
Exclusion Criteria:
- Medication that can affect study outcomes, as determined by the principal
investigator, including anti-diabetic medication
- Chronic diseases, acute inflammation, chronic renal failure (glomerular filtration
rate <45), or heart problems
We found this trial at
2
sites
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