Methylphenidate-Duloxetine Combinations for Cocaine Dependence
| Status: | Completed |
|---|---|
| Conditions: | Psychiatric |
| Therapuetic Areas: | Psychiatry / Psychology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 6/27/2018 |
| Start Date: | February 2016 |
| End Date: | June 2018 |
Randomized Clinical Trial: 03 (Methylphenidate and Duloxetine)
This study will determine the influence of methylphenidate (e.g., Ritalin®) and duloxetine
(Cymbalta®), alone and in combination, on the cocaine use as measured by self-report and
urine drug screens.
(Cymbalta®), alone and in combination, on the cocaine use as measured by self-report and
urine drug screens.
Inclusion Criteria:
- Recent cocaine use
- Seeking treatment for cocaine use
Exclusion Criteria:
- Abnormal screening outcome (e.g., ECG, blood chemistry result) that study physicians
deem clinically significant
- Current or past histories of substance abuse or dependence that are deemed by the
study physicians to interfere with study completion
- History of serious physical disease or current unstable physical disease (e.g., past
myocardial infarction, uncontrolled hypertension, diabetes, head trauma, seizures or
CNS tumors) or current or past histories of serious psychiatric disorder or suicidal
risk, other than substance abuse or dependence, will be excluded from research
participation
- Females not currently using effective birth control
- Contraindications to cocaine, methylphenidate or duloxetine
- Currently using opioids for pain or who are currently maintained on methadone or
buprenorphine for opioid use disorder will be excluded from participation
- Body weight less than 50 kg
We found this trial at
1
site
740 South Limestone Street
Lexington, Kentucky 40536
Lexington, Kentucky 40536
Principal Investigator: Craig R Rush, Ph.D.
Phone: 859-257-5388
Click here to add this to my saved trials
