Metabolic Adaptations to Chronic and Acute Exercise in Overweight Adults (ATX-Study)
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Healthy Studies, Obesity Weight Loss |
| Therapuetic Areas: | Endocrinology, Other |
| Healthy: | No |
| Age Range: | 18 - 40 |
| Updated: | 10/26/2018 |
| Start Date: | January 2016 |
| End Date: | January 2021 |
The primary purpose of this study is to examine the effects of chronic exercise training and
an acute session of exercise on key risk factors associated with Metabolic Syndrome (e.g.,
glucose tolerance, blood lipid profile, and blood pressure) and alterations in subcutaneous
adipose tissue structure and metabolic function in overweight adults.
an acute session of exercise on key risk factors associated with Metabolic Syndrome (e.g.,
glucose tolerance, blood lipid profile, and blood pressure) and alterations in subcutaneous
adipose tissue structure and metabolic function in overweight adults.
Subjects will be asked to complete the Substrate Metabolism Laboratory General Screening
Questionnaire and American Heart Association Health/Fitness Questionnaire to determine if
they are eligible to complete the preliminary testing procedures. If eligible, subjects will
be asked to visit the Substrate Metabolism Laboratory to participate in the preliminary
testing procedures (listed below) before participating in the experimental trial.
PRELIMINARY TESTING PROCEDURES:
- Blood pressure, height and weight measurements
- Body Composition Assessment (~20 min)
- Exercise Fitness Test (~10 min)
- Resting Metabolic Rate (RMR) measurement (~30 min)
- 3 hour Oral Glucose Tolerance Test (OGTT)
EXPERIMENTAL TRIAL:
The evening before the experimental trial, subjects will eat a standardized dinner meal and
snack. The meal and snack must be eaten at specific times as indicated by the research staff.
After eating the snack, subjects will need to fast (no food or beverages - besides water)
overnight.
Participants who exercise regularly will be instructed to exercise exactly 3 days before the
experimental trial, and then abstain from their exercise training program until after the
study is complete.
In the morning, subjects will return to the Substrate Metabolism Laboratory. The research
team will collect a blood sample from the subject's hand or forearm and a small sample of fat
tissue in the subject's abdomen with a needle. Next, subjects will exercise on a treadmill at
a moderate intensity for about 1 hour. Immediately after exercising the research team will
collect a second blood sample. Subjects will remain in the laboratory for 1 hour after
exercising, and then the research team will collect another blood and fat tissue sample. Upon
completion of the experimental trial, subjects will be provided a snack before leaving the
laboratory.
Questionnaire and American Heart Association Health/Fitness Questionnaire to determine if
they are eligible to complete the preliminary testing procedures. If eligible, subjects will
be asked to visit the Substrate Metabolism Laboratory to participate in the preliminary
testing procedures (listed below) before participating in the experimental trial.
PRELIMINARY TESTING PROCEDURES:
- Blood pressure, height and weight measurements
- Body Composition Assessment (~20 min)
- Exercise Fitness Test (~10 min)
- Resting Metabolic Rate (RMR) measurement (~30 min)
- 3 hour Oral Glucose Tolerance Test (OGTT)
EXPERIMENTAL TRIAL:
The evening before the experimental trial, subjects will eat a standardized dinner meal and
snack. The meal and snack must be eaten at specific times as indicated by the research staff.
After eating the snack, subjects will need to fast (no food or beverages - besides water)
overnight.
Participants who exercise regularly will be instructed to exercise exactly 3 days before the
experimental trial, and then abstain from their exercise training program until after the
study is complete.
In the morning, subjects will return to the Substrate Metabolism Laboratory. The research
team will collect a blood sample from the subject's hand or forearm and a small sample of fat
tissue in the subject's abdomen with a needle. Next, subjects will exercise on a treadmill at
a moderate intensity for about 1 hour. Immediately after exercising the research team will
collect a second blood sample. Subjects will remain in the laboratory for 1 hour after
exercising, and then the research team will collect another blood and fat tissue sample. Upon
completion of the experimental trial, subjects will be provided a snack before leaving the
laboratory.
Inclusion Criteria:
- Age: 18-40
- Body Mass Index: 25-35 kg/m2
- Regular exercisers: (≥4 days/wk of aerobic exercise; 30-60min/session at moderate and
vigorous intensities)
- Non-exercisers: no regularly planned exercise/physical activity
- Women must have regularly occurring menses and must be premenopausal
Exclusion Criteria:
- Blood pressure > 140/90 mm Hg
- Pregnant or lactating
- Evidence/history of cardiovascular or metabolic disease
- Medications known to affect lipid or glucose metabolism
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