Enhancing STDP After Spinal Cord Injury

Inclusion Criteria:

Participants who are unimpaired healthy controls:

- Male and females between ages 18-85 years

- Right handed

- Able to complete precision grips with both hands

- Able to complete full wrist flexion-extension bilaterally

- Able to walk unassisted

- Able to complete full ankle flexion-extension bilaterally

Participants who have had a spinal cord injury:

- Male and females between ages 18-85 years

- SCI ( 2 months of injury)

- Spinal Cord injury at or above L5

- The ability to produce a visible precision grip force with one hand

- Able to perform some small wrist flexion and extension

- The ability to perform a small visible contraction with dorsiflexion and hip flexor
muscles

- No subjects will be excluded based on their race, religion, ethnicity, gender or HIV
status.

- ASIA A,B,C, or D

Exclusion Criteria:

Exclusion criteria for enrollment For SCI and Healthy Control Subjects (4-8 exclusion for
non-invasive brain stimulation only):

- Uncontrolled medical problems including pulmonary, cardiovascular or orthopedic
disease

- Any debilitating disease prior to the SCI that caused exercise intolerance

- Premorbid, ongoing major depression or psychosis, altered cognitive status

- History of head injury or stroke

- Metal plate in skull

- History of seizures

- Receiving drugs acting primarily on the central nervous system, which lower the
seizure threshold (see appendix 2)

- Pregnant females

- Ongoing cord compression or a syrinx in the spinal cord or who suffer from a spinal
cord disease such as spinal stenosis, spina bifida, MS, or herniated disk

- Individuals with scalp shrapnel, cochlear implants, or aneurysm clips.