Measuring Blood Flow Characteristics Using Dynamic Contrast Enhanced Magnetic Resonance Imaging

Objectives The objective of this investigator-initiated study is to continue and extend this
research by applying our optimized DCE imaging protocol (using the standard FDA approved DCE
sequence) and our novel image post-processing to obtain new information about the BBB
integrity in trauma .

Study Procedure Overview: Patient's at LLUMC with an existing order for a MRI study of the
head with contrast will be asked if they would like to participate in the study to evaluate
if an optimized DCE sequence can provide more information about their disease.

Health controls will be asked if they would like to participate in the study in order to
evaluate if the optimized DCE sequence can provide useful information about various CNS
diseases.

Imaging: Following consent, subjects will be imaged at LLUMC using the 3T MRI scanner
(Siemens Medical Solutions, Malvern, PA) after MRI safety screening questionnaire is
complete. Subjects will be asked to lie on or be positioned on their backs in the MRI
scanner. The coil will be placed around their head and the subject will be provided with
headphones and/or earplugs during the scan. Imaging will consist of the diagnostic MR
protocol requested by the ordering physician and the addition of the standard FDA approved
DCE sequence.

Data Collection and Analysis The collected DCE data may be processed using standard FDA
approved DCE software (which the department already owns and uses clinically), used for
clinical decision making purposes, and added to the patients record. The data will also be
processed using specialized research software, this processing will not be used for
diagnostic or clinical decision making purposes, and will not be added to the patients
record. Ktrans values will be measured using region of interest analysis from the processed
DCE data to determine if there are differences between the pathology of interest and healthy
controls.

Inclusion Criteria:

- Any person between the ages of 0-100 years, who is undergoing routine magnetic
resonance imaging (MRI) with contrast at LLUMC.

Or

• Any person between the ages of 18-100 years, who agrees to undergo routine magnetic
resonance imaging (MRI) with contrast at LLUMC.

Exclusion Criteria:

- Electronic or metal implant that is not MRI safe, pregnancy or claustrophobia

- Not eligible for contrast agent injection (reduced renal function, GFR < 30 mL/min)