Brain Aging in Veterans (BRAVE) Training: A Cognitive Training Pilot Trial in Older Veterans With Traumatic Brain Injury

A study of older Veterans (60-85 years old) who have 1) a history of repetitive mild TBI or
at least one moderate TBI and 2) subjective cognitive complaints. Participants will be
randomized to one of three conditions for 4 weeks: Project:Evolution (EVO) multitask video
game, EVO words video game, or an assessment only control condition. Participants will
complete assessment visits at baseline, post-intervention (1 month after baseline), and 3
months post-intervention (4 months after baseline).

Inclusion Criteria:

1. Ages 60-85

2. Have experienced more than one mild TBI or at least one moderate TBI over their
lifetime

3. Have current cognitive problems based on self-report

4. Vision adequate to see test stimuli

5. Hearing adequate to understand the examiner

6. Fluent in English in order to understand task instructions

7. Demonstrate capacity to consent to participate in research

8. Mini-Mental Status Exam (MMSE) score ≥ 25

Exclusion Criteria:

1. History of penetrating brain injury

2. Active disabling neurological condition (e.g., stroke, brain tumor, multiple
sclerosis)

3. History of severe psychiatric illness (i.e., schizophrenia, bipolar disorder,
schizoaffective disorder)

4. Active drug use or active heavy alcohol use

5. History of severe TBI

6. History of a dementia diagnosis

7. Individuals who are physically unable to use an iPad for 30 minutes at a time per day
will be excluded, such as individuals with debilitating arthritis or tremor