RAD 1501: A Trial of Virtual Cone Trigeminal Neuralgia Radiosurgery

To determine the feasibility of frameless Virtual Cone trigeminal neuralgia radiosurgery at a
single institution prior to multi-institutional enrollment. To measure pain relief after
Virtual Cone radiosurgery utilizing the Barrow Neurologic Institute Pain Intensity Score
(BNI).

Inclusion Criteria:

- Patients with trigeminal neuralgia pain that is not well controlled despite medical
management (BNI 4 OR BNI 5)

- Patients must have an ECOG status of 0, 1, or 2

- Patients must be at least 18 years of age

- Life expectancy must be greater than 12 months

- MRI of brain within prior 12 months to confirm lack of other causes of facial pain

- All patients must be given written informed consent

Exclusion Criteria:

- Patients who have had prior brain radiosurgery or therapeutic radiation therapy to the
pons

- Patients with atypical trigeminal neuralgia or headache pain syndromes

- Patients with pain associated with multiple sclerosis or base of skull tumor

- Patients with medical contra-indications to MR imaging (e.g. pacemaker)