Prenatal DHA and Neurofunctional Development

Docosahexaenoic acid (DHA) is an essential nutrient. Our bodies make DHA from the foods we
eat. If we eat foods with a lot of DHA, like fatty ocean fish, we have more DHA in our
bodies. DHA is found in all cells of the body but is especially high in nerve cells of the
brain and eye. Babies get DHA from the mother when they're in the womb. After birth, they can
get DHA from breast milk or infant formulas.

This study will enroll pregnant women and follow them and their baby until the baby is 12
months old. Changes in the development of the baby will be tracked. Half of the participants
in this study will receive 200mg of DHA to take daily. The other half of participants will
receive 800mg of DHA to take daily. Participants, along with the researchers, will not know
which dose of DHA they are receiving.

Inclusion Criteria:

- Women in their 12th to 20th week of gestation

- Participants agree to consume the study capsules from enrollment to delivery

- Healthy weight, overweight and obese women (determined by body mass index; BMI) are
eligible

- Must be available by telephone

Exclusion Criteria:

- Underweight women and women who exceed 250 lbs at enrollment

- Women with serious systemic infection, cancer, major organ disease or systemic lupus
erythematosus

- Women with multiple infants or fetal diagnosis of congenital cardiac structural or
conduction defects or brain malformations

- Diagnosis of Type I diabetes, and/or hypertension

- Reported drug and/or alcohol abuse

- Unwilling to take capsules, or be contacted by phone

- Do not understand English