Indocyanine Green for Central Nervous System Tumors
| Status: | Recruiting |
|---|---|
| Conditions: | Brain Cancer, Brain Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 11/2/2018 |
| Start Date: | August 2015 |
| Contact: | John Lee, MD |
| Email: | PennCancerTrials@emergingmed.com |
| Phone: | 855-216-0098 |
A Pilot/Feasibility Study of Intraoperative Image-Guided Surgery of CNS Tumors With Indocyanine Green and MR Spectroscopic Imaging
A specific aim is to determine if Indocyanine Green (ICG) administered pre-operatively, then
imaged intraoperatively using our camera will aid in the identification of suspected central
nervous system (CNS) tumors. A secondary aim is to understand if the use of ICG during
surgery correlates to MR imaging findings including elevated Cho/Cr ratio, rCBV, Ktrans and
contrast enhancement.
imaged intraoperatively using our camera will aid in the identification of suspected central
nervous system (CNS) tumors. A secondary aim is to understand if the use of ICG during
surgery correlates to MR imaging findings including elevated Cho/Cr ratio, rCBV, Ktrans and
contrast enhancement.
Inclusion Criteria:
- Adult patients 18 years of age and older.
- Patients presenting with a CNS tumor presumed to be resectable and are at risk for
local recurrence on pre-operative assessment
- Good operative candidate as determined by the treating physician and multidisciplinary
team
- Subject capable of giving informed consent and participating in the process of
consent.
Exclusion Criteria:
- Pregnant women as determined by urinary or serum beta hCG within 72 hours of surgery
- Subjects with a history of iodide allergies
- Vulnerable patient populations
a. Patients unable to participate in the consent process (children and neonates).
- Patients with non-MRI compatible implanted metallic foreign bodies are excluded from
this study"
- Patients who due to severe claustrophobia cannot tolerate MRI scanning"
- Patients with a known allergy or hypersensitivity to MRI contrast agents including
gadolinium .
We found this trial at
1
site
3400 Civic Center Blvd
Philadelphia, Pennsylvania 19104
Philadelphia, Pennsylvania 19104
(215) 662-6065
Phone: 855-216-0098
Abramson Cancer Center of the University of Pennsylvania The Abramson Cancer Center of the University...
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