Body Composition and White Adipose Tissue Inflammation

Status:	Recruiting
Conditions:	Breast Cancer, Prostate Cancer, Cancer, Cancer
Therapuetic Areas:	Oncology
Healthy:	No
Age Range:	18 - Any
Updated:	7/1/2018
Start Date:	November 4, 2015
End Date:	November 2019
Contact:	Neil Iyengar, MD
Phone:	646-888-4714

The investigators want to find a better way to predict the risk of having fatty tissue
inflammation by using a different approach to finding out body fat composition. In this
study, the investigators want to estimate the body fat composition using a DEXA scan. DEXA
stands for dual energy X-ray absorptiometry. It is the standard and established test to
determine bone mineral density (how strong the bones are) to diagnose osteoporosis. This test
can also be used to determine the body composition including percent body fat and lean mass.
The investigators will compare the participants DEXA scan results for body fat composition to
the inflammation found in the breast tissue from the mastectomy to see if there is a
relationship. If successful, this may help us predict which patients may be at risk for
breast cancer in the future. In addition, the investigators will compare the participants
DEXA scan results for body fat composition and inflammation found in the fat tissue from the
mastectomy or prostatectomy to the level of exercise activity as measured by a short
questionnaire to see if there is a relationship. The investigators will also measure the
participants waist to hip ratio.

Finally, at the time the participant has blood drawn for their standard presurgical testing,
the investigators will also test the blood for prediabetes using a blood test called
hemoglocin A1c. The investigators will also measure for the participants waist to hip ratio,
and a Hgb A1c blood drawn will be take at the time of presurgical testing. If not feasible,
Hgb A1c can be drawn at a separate visit prior to the DEXA scan. If successful, this may help
us predict which patients may be at risk for breast cancer in the future.

Inclusion Criteria:

- Age ≥ 18

- Female or male

- All BMIs

- Patients undergoing mastectomy at MSKCC (i.e. Nipple-sparing mastectomy, skin-sparing
mastectomy, simple mastectomy, modified radical mastectomy, radical mastectomy);
mastectomy may be either prophylactic or therapeutic. OR

- Patients undergoing radical prostatectomy at MSKCC

- History of prior breast surgeries/procedures is acceptable

Exclusion Criteria:

- Pregnancy (confirmed or suspected);

- Inability to lay supine on equipment table and maintain the position for the necessary
time;

- Weight superior to the maximum allowed by the DEXA machine (over 350 lbs or 158 kg);

- Greater than 10% baseline weight loss in the past year;

- Planned surgical procedure is not a Mastectomy (i.e. breast conservation surgery or
other non-mastectomy procedure; such as lumpectomy)

- Metastatic cancer

- History of Wasting Syndromes or Cachexia

- Use of daily NSAIDs, aspirin, or steroids (other than inhaled or topical) within 30
days of surgery

- Use of neoadjuvant systemic or radiation therapy.

We found this trial at

sites

Memoral Sloan Kettering Cancer Center

Basking Ridge, New Jersey

Phone: 646-888-4714

from

Basking Ridge, NJ