A Study to Evaluate LY3202328 in Overweight Healthy Participants and Dyslipidemia

Inclusion Criteria:

- Be healthy, as determined by medical history and physical examination

- Male participants must agree to use a reliable method of birth control during the
study and 3 months following the last dose of the investigational product

- Female participants must be between 40 and 70 years old, and either postmenopausal or
with a hysterectomy, and not pregnant and not lactating

- Be on a stable diet and exercise regimen for greater than (>) 3 months prior

- Have a body mass index (BMI) of 25.0 (Part A) or 27.0 (Part B) to 40.0 kilograms per
meter squared

- Have fasting triglycerides (TG) between 150 and 499 milligrams per deciliter (mg/dL)
(Part B only)

- Have a fasting low-density lipoprotein cholesterol (LDL-c) between 100 and 200 mg/dL
(Part B only)

- Have estimated glomerular filtration rate greater than or equal to (≥) 60 milliliters
per minute/1.73 meter squared with no proteinuria

- Be normotensive defined as supine systolic blood pressure (BP) less than or equal to
(≤) 150 millimeters of mercury (mm Hg) and diastolic BP ≤ 100 mm Hg, without the use
of any antihypertensive

Exclusion Criteria:

- Are taking a statin, any proprotein convertase subtilisin/kexin type 9 (PCSK9)
medications, or have started taking other TG lowering agents (for example, niacin,
fish oils)

- Are currently enrolled in a clinical trial involving an investigational product or
off-label use of a drug or device, or are concurrently enrolled in any other type of
medical research, or have participated in a clinical trial involving an
investigational product or non-approved use of a drug within the last 30 days or
within 5 half-lives

- Have an abnormal electrocardiogram or corrected QT or are on antihypertensive
treatment

- Have any current or prior history of significant cardiovascular disease

- Show evidence of hepatitis C virus (HCV), Hepatitis B or other chronic liver disease

- Have an alcohol intake that exceeds 7 units per week with no more than 3 units per
day, or are unwilling to stop alcohol consumption for the duration of the study (1
unit = 12 ounces or 360 mL of beer; 5 ounces or 150 mL of wine; 1.5 ounces or 45 mL
of distilled spirits), or are a regular user of known drugs of abuse

- Have a history of untreated endocrine illness such as diabetes mellitus

- Have been on medications or supplements for weight loss within 3 months

- Have a history of active neuropsychiatric disease or on pharmacological therapy for
such conditions (Part B, only)

- Show evidence of human immunodeficiency virus (HIV) infection

- Have been on medications that are known to inhibit cytochrome P450, family 3,
subfamily A (CYP3A) or P-glycoprotein (P-gp), or regularly consume grapefruit

- Have donated blood of more than 500 mL within the last month

- Smoke >10 cigarettes per day or are unwilling to follow smoking rules