Extended Treatment Access Study of MT-3724 for Subjects With Relapsed Non-Hodgkin's B-Cell Lymphoma

Each treatment cycle will consist of 6 doses of MT-3724 to be administered over 12 days
followed by at least 9 days of observation but longer intervals between dosing cycles will be
allowed at the investigator's discretion (e.g., 6 doses of MT-3724 over 12 days followed by
16 days observation). Subjects in this extension study may continue to receive up to 6
additional cycles in the absence of clear disease progression or toxicity. If a subject
achieves complete remission, two additional cycles will be attempted, after which dosing may
be suspended prior to completion of the maximum 6 cycles.

Inclusion Criteria:

- Eligible subjects must be adequately informed of all study procedures and fully
consent to participation as demonstrated by signing the Informed Consent Form (ICF).

- Eligible subjects must require treatment for their NHL and have:

- tolerated MT-3724 throughout the MT-3724_NHL_001_US Phase I/Ib study (Core and
Repeat Dosing),

- successfully completed the Core and Repeat Dosing portions of MT-3724_NHL_001_US
Phase I/Ib study as defined by that protocol,

- received no other treatment for their NHL since enrollment in the
MT-3724_NHL_001_US Phase I/Ib study,

- maintained stable disease or better throughout that study and

- been assessed by the investigator to have no other acceptable and better
treatment options available to them. The investigator must document in the
potential subject's medical record that there are no other approved treatment
options available and/or appropriate for the potential subject or that the
potential subject has declined any other approved treatment options that me be
available to them.

- Potential subjects must continue to meet the diagnostic criteria for B-Cell NHL that
allowed them to be eligible for the MT-3724_NHL_001_US Phase I/Ib study.

- Potential subjects must have received all approved therapies known to provide clinical
benefit for their disease subtype and for which they are eligible or must have refused
these treatment options prior to consideration for continued compassionate use
treatment with MT-3724 through enrollment in this protocol. In the case of subjects
who have lymphomas for which high-dose chemotherapy and autologous stem cell
transplantation (HD-ASCT) is considered a standard curative therapy, eligibility for
MT-3724 compassionate use requires that the subject's disease relapsed after HD-ASCT,
that the subject is not eligible for HD ASCT, or that the subject has refused HD-ASCT.

- Potential subjects with known central nervous system (CNS) metastases may be enrolled
if they:

- have previously been treated with radiotherapy for their CNS disease,

- do not require chronic steroid therapy,

- have had computed tomography or magnetic resonance imaging of the brain within 1
month of this study's entry that showed stable disease and

- have no neurological symptoms (excluding Grade 1 or 2 neuropathy).

- Eastern Cooperative Oncology Group (ECOG) performance status of < 3

- Potential subjects should have measurable disease (any tumor mass of at least 1.5 cm)
which has been documented to not have progressed during the MT-3724_NHL_001_US Phase
I/Ib study and which can be followed during extended treatment for possible new
disease progression.

- Potential subjects must be at least 9 days past their last course of MT-3724 treatment
and have recovered from any side effects attributed to MT-3724 to at least Common
Terminology Criteria for Adverse Events (CTCAE, v. 4.03; Appendix 4) Grade 2 prior to
initiating additional cycles of MT-3724 through this compassionate use protocol.
Subjects with pre-existing AEs at screening that are severe or life threatening by
CTCAE grading should not be enrolled.

- Laboratory requirements:

- Absolute neutrophil count (ANC) > 1,000 per microliter (μL)

- Platelet count > 25,000/μL (The potential subject must be asymptomatic and the
thrombocytopenia must be secondary to bone marrow infiltration by tumor and not
secondary to increased platelet consumption or the effect of previous marrow
suppressing treatment or infection.)

- Hemoglobin ≥ 8.0 g/dL

- Total bilirubin < 1.5 times upper limit of normal (ULN) (unless due to Gilbert's
Disease)

- Aspartate aminotransferase (AST; SGOT) and alanine aminotransferase (ALT; SGPT) <
2.5 times ULN or < 5x ULN if liver metastases are present

- Serum creatinine ≤ 1.5 x ULN or creatinine clearance ≥ 50 ml/min (either measured
or estimated by the Cockcroft-Gault formula).

- Females of childbearing potential must have a negative serum or urine pregnancy test
within 3 days prior to initiating dosing. Male and female subjects with reproductive
potential must agree to use appropriate contraceptive methods while on study therapy
and for 84 days following their last dose of study medication.

Exclusion Criteria:

- Patients who cannot comply with protocol requirements including clinic visits for
intravenous infusions and birth control measures may not be enrolled.

- Female patients who are pregnant or are breast feeding.

- Potential patients with a history of another cancer other than basal cell carcinoma or
cervical intraepithelial neoplasia (cervical cancer in situ) may not be enrolled
unless it is documented that their previous cancer was treated, they have been disease
free for five or more years prior to starting this study and they are in their
doctor's judgment at less than 30% risk of relapse of this previous malignancy.

- Patients with a peripheral blood total lymphocyte count of higher than 25,000/mm3 may
not be enrolled.

- Patients cannot have experienced a significant (CTCAE Grade 3 or 4 with or without
neutropenia) infection within 2 weeks of their first dose of MT-3724.

- Patients are not eligible if they are using any other approved or investigational
anti-neoplastic therapies or any other investigational therapies for any other reason.

- Patients may not be receiving systemic corticosteroid therapy at a prednisone dose >
20 mg/day (or steroid equivalent) within 2 weeks of starting study.

- Patients with uncontrolled or severe cardiovascular disease, including myocardial
infarct or unstable angina within 6 months prior to start of study treatment, New York
Heart Association (NYHA) Class II or greater congestive heart failure, serious
arrhythmias requiring medication for treatment, clinically significant pericardial
disease, or cardiac amyloidosis may not be enrolled.

- Patients with a known history of drug abuse or any chronic neurologic, psychiatric,
endocrine, metabolic, immunologic, hepatic or renal disease (including a history of
hemolytic uremic syndrome) that in the opinion of the Investigator would adversely
affect study participation.

- Patients with known active Hepatitis C, HIV or a present history of Hepatitis B

- Patients must not have received any vaccines for 28 days prior to administration of
their first dose of MT-3724 and should not receive any vaccine during the study or
within 28 days after their last dose of MT-3724.

- Patients with a suspected allergy or sensitivity to any component of MT-3724 drug
preparation based upon known allergies to compounds of a similar class who have had an
anaphylactic or other severe infusion reaction to human immunoglobulin or monoclonal
antibody administration are n ot eligible.

- Patients who have had an allogeneic hematopoietic stem cell transplantation are not
eligible.

- Patients who have had major surgery within 6 weeks prior to the first dose of study
drug or have major surgery planned during the first 12 weeks after MT-3724 has
finished.