Contrast Ultrasound Perfusion Imaging in PAD With Sonazoid
| Status: | Recruiting |
|---|---|
| Conditions: | Peripheral Vascular Disease |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | 19 - Any |
| Updated: | 12/31/2016 |
| Start Date: | January 2016 |
| End Date: | December 2016 |
The measurement of limb skeletal muscle perfusion and perfusion reserve during exercise is
an approach that can assess the total impact of the complex pathophysiologic processes in
patients with limb ischemia, particularly in those with diabetes in whom distal arterial
disease and abnormal microvascular functional responses are common. This trial is designed
to: (a) optimize methods for assessment of limb perfusion at rest and during stress using
contrast-enhanced ultrasound (normal subjects) and a microbubble contrast agent that is able
to provide non-linear signal without destruction at medium acoustic pressures, and (b) to
test whether perfusion imaging provides incremental information on the severity of disease
in patients with peripheral artery disease.
an approach that can assess the total impact of the complex pathophysiologic processes in
patients with limb ischemia, particularly in those with diabetes in whom distal arterial
disease and abnormal microvascular functional responses are common. This trial is designed
to: (a) optimize methods for assessment of limb perfusion at rest and during stress using
contrast-enhanced ultrasound (normal subjects) and a microbubble contrast agent that is able
to provide non-linear signal without destruction at medium acoustic pressures, and (b) to
test whether perfusion imaging provides incremental information on the severity of disease
in patients with peripheral artery disease.
Inclusion Criteria:
- For Healthy controls: no active major medical problems or vasoactive medications
- For PAD: Known diagnosis with PAD an ABI of 0.4-0.6
Exclusion Criteria:
- Rutherford class 6 or greater
- Allergy to ultrasound contrast agents
- Previous limb amputation
- Pregnancy
- Known congenital or acquired right to left shunt
We found this trial at
1
site
3181 Southwest Sam Jackson Park Road
Portland, Oregon 97239
Portland, Oregon 97239
503 494-8311
Phone: 503-494-8750
Oregon Health and Science University In 1887, the inaugural class of the University of Oregon...
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