Collection of Blood From Patients With Pancytopenia
| Status: | Completed |
|---|---|
| Conditions: | Anemia, Hematology |
| Therapuetic Areas: | Hematology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 3/20/2019 |
| Start Date: | April 30, 1986 |
Lymphocytapheresis of Patients With Pancytopenia
Aplastic anemia is a condition in which the cells normally found in blood are greatly
decreased. The normal levels of white blood cells, red blood cells, and platelets are much
lower in patients with aplastic anemia.
Because of these low levels of blood cells, patients with aplastic anemia have a variety of
immune system abnormalities. However, low levels of blood cells make it difficult to collect
specialized white blood cells (mononuclear cells) for research studies.
This study was designed to collect lymphocytes from patients with low levels of all blood
cells (pancytopenia) for use in research. Patients participating in the study will undergo a
special procedure known as lymphapheresis. During lymphapheresis blood is taken from the
patient in a manner similar to blood donation. The white blood cells are selectively removed
by spinning (centrifugation), and the remaining red blood cells and platelets are placed back
(re-infused) into the donor s blood stream.
Patients participating in this study will not benefit directly from it. However, cells
collected in this study may increase scientific knowledge and improve understanding and
treatment for diseases like aplastic anemia.
decreased. The normal levels of white blood cells, red blood cells, and platelets are much
lower in patients with aplastic anemia.
Because of these low levels of blood cells, patients with aplastic anemia have a variety of
immune system abnormalities. However, low levels of blood cells make it difficult to collect
specialized white blood cells (mononuclear cells) for research studies.
This study was designed to collect lymphocytes from patients with low levels of all blood
cells (pancytopenia) for use in research. Patients participating in the study will undergo a
special procedure known as lymphapheresis. During lymphapheresis blood is taken from the
patient in a manner similar to blood donation. The white blood cells are selectively removed
by spinning (centrifugation), and the remaining red blood cells and platelets are placed back
(re-infused) into the donor s blood stream.
Patients participating in this study will not benefit directly from it. However, cells
collected in this study may increase scientific knowledge and improve understanding and
treatment for diseases like aplastic anemia.
Patients with aplastic anemia, myelodysplasia, and other marrow failure syndromes have a
variety of immunologic abnormalities including lymphocyte phenotypic and lymphokine
production dysregulation. Because of their low blood counts, it has been difficult to obtain
sufficient peripheral blood mononuclear cells for research studies. Patients agreeing to this
protocol will be lymphapheresed the equivalent of one or two units of cells (approximately
1-2 x 10(8) cells), which will be used for research purposes.
variety of immunologic abnormalities including lymphocyte phenotypic and lymphokine
production dysregulation. Because of their low blood counts, it has been difficult to obtain
sufficient peripheral blood mononuclear cells for research studies. Patients agreeing to this
protocol will be lymphapheresed the equivalent of one or two units of cells (approximately
1-2 x 10(8) cells), which will be used for research purposes.
- INCLUSION CRITERIA:
All patients with aplastic anemia or other bone marrow failure in which we would not expect
to obtain 1 X 10(8) mononuclear cells from 100 mls of peripheral blood (i.e. an absolute
lymphocyte count approximately less than 2000 per mm(3)).
Age greater than or equal to 18.
EXCLUSION CRITERIA:
Patients unable to comprehend the investigational nature of the procedure.
Patients unable to tolerate a temporary reduction of blood volume the equivalent of one
unit of blood.
We found this trial at
1
site
9000 Rockville Pike
Bethesda, Maryland 20892
Bethesda, Maryland 20892
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