Structure of the Herpes Simplex Virus Receptor
| Status: | Completed |
|---|---|
| Conditions: | Skin Cancer, Skin and Soft Tissue Infections, Infectious Disease, Infectious Disease |
| Therapuetic Areas: | Dermatology / Plastic Surgery, Immunology / Infectious Diseases, Oncology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/21/2016 |
| Start Date: | August 1997 |
| End Date: | April 2010 |
Polymorphism of the Herpes Simplex Virus Receptor
This study will examine the structure of the receptor molecule for the herpes simplex virus
(HSV) and determine if the receptor's structure is related to susceptibility to infection
with the virus. There are two types of herpes virus-HSV-1 and HSV-2. HSV-1 commonly causes
cold sores, and HSV-2 usually causes genital herpes. The herpes virus enters (infects) cells
through protein molecules on the cell's surface. This study will explore possible
differences between the structure of the HSV receptor molecule in different people to
understand better how infection occurs. The study will also look at proteins on white blood
cells (Fc receptors, cytokines and mannose binding protein) that may influence the risk of
infection with HSV. Information from this study may lead to new treatments to prevent HSV
infection.
People 18 years of age and older who are infected with HSV and people who are not infected
with the virus may be eligible for this study. Participants will have blood drawn to confirm
whether or not they have been infected with the virus. The blood sample will also be used to
study the genes for the HSV receptor, Fc receptors, cytokines, mannose binding protein and
related proteins on the white blood cells. No more than 40 milliliters (8 teaspoons) of
blood will be drawn.
Participants who are found to have antibodies to HSV-2 will be offered counseling and advice
on practicing safe sex techniques to help prevent sexually transmitted diseases, including
HSV-2 infection.
(HSV) and determine if the receptor's structure is related to susceptibility to infection
with the virus. There are two types of herpes virus-HSV-1 and HSV-2. HSV-1 commonly causes
cold sores, and HSV-2 usually causes genital herpes. The herpes virus enters (infects) cells
through protein molecules on the cell's surface. This study will explore possible
differences between the structure of the HSV receptor molecule in different people to
understand better how infection occurs. The study will also look at proteins on white blood
cells (Fc receptors, cytokines and mannose binding protein) that may influence the risk of
infection with HSV. Information from this study may lead to new treatments to prevent HSV
infection.
People 18 years of age and older who are infected with HSV and people who are not infected
with the virus may be eligible for this study. Participants will have blood drawn to confirm
whether or not they have been infected with the virus. The blood sample will also be used to
study the genes for the HSV receptor, Fc receptors, cytokines, mannose binding protein and
related proteins on the white blood cells. No more than 40 milliliters (8 teaspoons) of
blood will be drawn.
Participants who are found to have antibodies to HSV-2 will be offered counseling and advice
on practicing safe sex techniques to help prevent sexually transmitted diseases, including
HSV-2 infection.
Herpes simplex virus (HSV) causes genital, orolabial, or cutaneous lesions, keratitis, and
encephalitis. Recently cellular receptors for HSV were isolated. The purpose of this study
is to identify polymorphisms in the sequence of HSV receptor, cytokines or chemokines and to
determine whether these polymorphisms correlate with susceptibility to infection by HSV or
with symptoms of HSV. Blood samples from individuals who are seronegative, or seropositive
(with or without symptoms of infection) for HSV-2 will be analyzed to determine the
sequences of the HSV receptors, cytokines, chemokines, or related proteins. If a new genetic
polymorphism is found, additional blood samples from individuals who are seropositive for
HSV and from random blood donors will be analyzed to determine the frequency of the
polymorphisms in seropositives and in the general population. Knowledge gained from this
study should provide important insights into mechanisms of infection by HSV and may lead to
novel therapies to block infection.
encephalitis. Recently cellular receptors for HSV were isolated. The purpose of this study
is to identify polymorphisms in the sequence of HSV receptor, cytokines or chemokines and to
determine whether these polymorphisms correlate with susceptibility to infection by HSV or
with symptoms of HSV. Blood samples from individuals who are seronegative, or seropositive
(with or without symptoms of infection) for HSV-2 will be analyzed to determine the
sequences of the HSV receptors, cytokines, chemokines, or related proteins. If a new genetic
polymorphism is found, additional blood samples from individuals who are seropositive for
HSV and from random blood donors will be analyzed to determine the frequency of the
polymorphisms in seropositives and in the general population. Knowledge gained from this
study should provide important insights into mechanisms of infection by HSV and may lead to
novel therapies to block infection.
- INCLUSION CRITERIA:
HSV-2 Seronegative Patients:
Individuals known or likely to be seronegative for HSV-2 will be recruited.
All racial, gender, and ethnic groups will be considered.
Adult volunteers at least 18 years of age.
Volunteers who were seronegative for HSV-2 (regardless of HSV-1 serology) confirmed by
Western blot.
Volunteers are willing to allow investigators to store their blood.
HSV-2 seropositive patients (with or without symptoms):
All racial and ethnic groups will be considered.
Volunteers who were seropositive for HSV-2 (regardless of HSV-1 serology) confirmed by
Western blot.
Volunteers are willing to allow investigators to store their blood.
Normal Controls:
To determine the frequency of a genetic polymorphism in a population that has not had
prior screening for HSV, blood may be obtained from normal control blood donors.
We found this trial at
1
site
9000 Rockville Pike
Bethesda, Maryland 20892
Bethesda, Maryland 20892
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